1239--9--3-[2--1--1-]-4--4- PROCESS FOR THE PREPARATION OF 1239-TETRAHYDRO-9-METHYL-3-[2-METHYL-1H-IMIDAZOL-1-YLMETHYL]-4H-CARBAZOL-4-ONE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
PURPOSE: Provided is a novel manufacturing method of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl))-4H-carbazol-4-on or its pharmaceutically acceptable salt in higher yield and purity than conventional methods. CONSTITUTION: The manufacturing method is characterized by reacting 1,2,3,9-...
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| creator | LEE, GWANG OK JUNG, GEUM SIN KIM, GI EUN LEE, HOE CHEOL KIM, MAENG SEOP LEE, GWAN SUN KIM, HUI SEOK HAM, YEONG JIN KIM, CHEOL GYEONG KIM, HAN GYEONG |
| description | PURPOSE: Provided is a novel manufacturing method of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl))-4H-carbazol-4-on or its pharmaceutically acceptable salt in higher yield and purity than conventional methods. CONSTITUTION: The manufacturing method is characterized by reacting 1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-on of the formula(2) with 2-methylimidazole derivative of the formula(3) in a mixed solvent of organic solvent and water at room temperature to 150 deg.C fro 2-12 hours to manufacture 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl))-4H-carbazol-4-on of the formula(1) or its pharmaceutically acceptable salt.
본 발명은 할로실란 화합물 존재하에서 하기 화학식 2의 1,2,3,9-테트라히드로-9-메틸-4H-카바졸-4-온을 화학식 3의 2-메틸이미다졸 유도체와 유기용매 또는 유기용매와 물의 혼합용매 중에서 반응시키는 것을 특징으로 하는, 화학식 1의 1,2,3,9-테트라히드로-9-메틸-3-[(2-메틸-1H-이미다졸-1-일)메틸]-4H-카바졸-4-온 또는 그의 약제학적으로 허용가능한 염의 제조 방법에 관한 것으로, 본 발명의 방법에 따르면 보다 간단한 공정으로 목적 화합물을 고수율, 고순도로 제조할 수 있다. 상기 식에서, R은 N,N-디메틸아미노, N,N-디에틸아미노, N,N-디프로필아미노, 몰포린-4-일, 피페리딘-1-일 또는 피롤리딘-1-일이다. |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_KR20020039223A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>KR20020039223A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_KR20020039223A3</originalsourceid><addsrcrecordid>eNqNjk0KwkAMhbtxIeodBlwH7Iwbl3GaMsWpU9K4qCJSZFyJCno2z-f4cwDhg7yE5L0Ms2euzQIgYWCnAfI3e5hDQjUcLLWtKgMrcZR6apBRqrBWoVSfUyFhdF3BIZnUJK7zX6ufzh1UdVXgNiQNnf-OU4IDi7z8zOcQ1qRSSOOQa7S0kcqi951Ca6kRXHpSLXpp328whXKcDU79-R4nvzrKpiWJdRBv10O83_pjvMTHYcV6NkuYhdYGzX9bL1VGSTA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>1239--9--3-[2--1--1-]-4--4- PROCESS FOR THE PREPARATION OF 1239-TETRAHYDRO-9-METHYL-3-[2-METHYL-1H-IMIDAZOL-1-YLMETHYL]-4H-CARBAZOL-4-ONE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF</title><source>esp@cenet</source><creator>LEE, GWANG OK ; JUNG, GEUM SIN ; KIM, GI EUN ; LEE, HOE CHEOL ; KIM, MAENG SEOP ; LEE, GWAN SUN ; KIM, HUI SEOK ; HAM, YEONG JIN ; KIM, CHEOL GYEONG ; KIM, HAN GYEONG</creator><creatorcontrib>LEE, GWANG OK ; JUNG, GEUM SIN ; KIM, GI EUN ; LEE, HOE CHEOL ; KIM, MAENG SEOP ; LEE, GWAN SUN ; KIM, HUI SEOK ; HAM, YEONG JIN ; KIM, CHEOL GYEONG ; KIM, HAN GYEONG</creatorcontrib><description>PURPOSE: Provided is a novel manufacturing method of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl))-4H-carbazol-4-on or its pharmaceutically acceptable salt in higher yield and purity than conventional methods. CONSTITUTION: The manufacturing method is characterized by reacting 1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-on of the formula(2) with 2-methylimidazole derivative of the formula(3) in a mixed solvent of organic solvent and water at room temperature to 150 deg.C fro 2-12 hours to manufacture 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl))-4H-carbazol-4-on of the formula(1) or its pharmaceutically acceptable salt.
본 발명은 할로실란 화합물 존재하에서 하기 화학식 2의 1,2,3,9-테트라히드로-9-메틸-4H-카바졸-4-온을 화학식 3의 2-메틸이미다졸 유도체와 유기용매 또는 유기용매와 물의 혼합용매 중에서 반응시키는 것을 특징으로 하는, 화학식 1의 1,2,3,9-테트라히드로-9-메틸-3-[(2-메틸-1H-이미다졸-1-일)메틸]-4H-카바졸-4-온 또는 그의 약제학적으로 허용가능한 염의 제조 방법에 관한 것으로, 본 발명의 방법에 따르면 보다 간단한 공정으로 목적 화합물을 고수율, 고순도로 제조할 수 있다. 상기 식에서, R은 N,N-디메틸아미노, N,N-디에틸아미노, N,N-디프로필아미노, 몰포린-4-일, 피페리딘-1-일 또는 피롤리딘-1-일이다.</description><edition>7</edition><language>eng ; kor</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2002</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20020525&DB=EPODOC&CC=KR&NR=20020039223A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20020525&DB=EPODOC&CC=KR&NR=20020039223A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LEE, GWANG OK</creatorcontrib><creatorcontrib>JUNG, GEUM SIN</creatorcontrib><creatorcontrib>KIM, GI EUN</creatorcontrib><creatorcontrib>LEE, HOE CHEOL</creatorcontrib><creatorcontrib>KIM, MAENG SEOP</creatorcontrib><creatorcontrib>LEE, GWAN SUN</creatorcontrib><creatorcontrib>KIM, HUI SEOK</creatorcontrib><creatorcontrib>HAM, YEONG JIN</creatorcontrib><creatorcontrib>KIM, CHEOL GYEONG</creatorcontrib><creatorcontrib>KIM, HAN GYEONG</creatorcontrib><title>1239--9--3-[2--1--1-]-4--4- PROCESS FOR THE PREPARATION OF 1239-TETRAHYDRO-9-METHYL-3-[2-METHYL-1H-IMIDAZOL-1-YLMETHYL]-4H-CARBAZOL-4-ONE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF</title><description>PURPOSE: Provided is a novel manufacturing method of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl))-4H-carbazol-4-on or its pharmaceutically acceptable salt in higher yield and purity than conventional methods. CONSTITUTION: The manufacturing method is characterized by reacting 1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-on of the formula(2) with 2-methylimidazole derivative of the formula(3) in a mixed solvent of organic solvent and water at room temperature to 150 deg.C fro 2-12 hours to manufacture 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl))-4H-carbazol-4-on of the formula(1) or its pharmaceutically acceptable salt.
본 발명은 할로실란 화합물 존재하에서 하기 화학식 2의 1,2,3,9-테트라히드로-9-메틸-4H-카바졸-4-온을 화학식 3의 2-메틸이미다졸 유도체와 유기용매 또는 유기용매와 물의 혼합용매 중에서 반응시키는 것을 특징으로 하는, 화학식 1의 1,2,3,9-테트라히드로-9-메틸-3-[(2-메틸-1H-이미다졸-1-일)메틸]-4H-카바졸-4-온 또는 그의 약제학적으로 허용가능한 염의 제조 방법에 관한 것으로, 본 발명의 방법에 따르면 보다 간단한 공정으로 목적 화합물을 고수율, 고순도로 제조할 수 있다. 상기 식에서, R은 N,N-디메틸아미노, N,N-디에틸아미노, N,N-디프로필아미노, 몰포린-4-일, 피페리딘-1-일 또는 피롤리딘-1-일이다.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2002</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjk0KwkAMhbtxIeodBlwH7Iwbl3GaMsWpU9K4qCJSZFyJCno2z-f4cwDhg7yE5L0Ms2euzQIgYWCnAfI3e5hDQjUcLLWtKgMrcZR6apBRqrBWoVSfUyFhdF3BIZnUJK7zX6ufzh1UdVXgNiQNnf-OU4IDi7z8zOcQ1qRSSOOQa7S0kcqi951Ca6kRXHpSLXpp328whXKcDU79-R4nvzrKpiWJdRBv10O83_pjvMTHYcV6NkuYhdYGzX9bL1VGSTA</recordid><startdate>20020525</startdate><enddate>20020525</enddate><creator>LEE, GWANG OK</creator><creator>JUNG, GEUM SIN</creator><creator>KIM, GI EUN</creator><creator>LEE, HOE CHEOL</creator><creator>KIM, MAENG SEOP</creator><creator>LEE, GWAN SUN</creator><creator>KIM, HUI SEOK</creator><creator>HAM, YEONG JIN</creator><creator>KIM, CHEOL GYEONG</creator><creator>KIM, HAN GYEONG</creator><scope>EVB</scope></search><sort><creationdate>20020525</creationdate><title>1239--9--3-[2--1--1-]-4--4- PROCESS FOR THE PREPARATION OF 1239-TETRAHYDRO-9-METHYL-3-[2-METHYL-1H-IMIDAZOL-1-YLMETHYL]-4H-CARBAZOL-4-ONE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF</title><author>LEE, GWANG OK ; JUNG, GEUM SIN ; KIM, GI EUN ; LEE, HOE CHEOL ; KIM, MAENG SEOP ; LEE, GWAN SUN ; KIM, HUI SEOK ; HAM, YEONG JIN ; KIM, CHEOL GYEONG ; KIM, HAN GYEONG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20020039223A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2002</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>LEE, GWANG OK</creatorcontrib><creatorcontrib>JUNG, GEUM SIN</creatorcontrib><creatorcontrib>KIM, GI EUN</creatorcontrib><creatorcontrib>LEE, HOE CHEOL</creatorcontrib><creatorcontrib>KIM, MAENG SEOP</creatorcontrib><creatorcontrib>LEE, GWAN SUN</creatorcontrib><creatorcontrib>KIM, HUI SEOK</creatorcontrib><creatorcontrib>HAM, YEONG JIN</creatorcontrib><creatorcontrib>KIM, CHEOL GYEONG</creatorcontrib><creatorcontrib>KIM, HAN GYEONG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LEE, GWANG OK</au><au>JUNG, GEUM SIN</au><au>KIM, GI EUN</au><au>LEE, HOE CHEOL</au><au>KIM, MAENG SEOP</au><au>LEE, GWAN SUN</au><au>KIM, HUI SEOK</au><au>HAM, YEONG JIN</au><au>KIM, CHEOL GYEONG</au><au>KIM, HAN GYEONG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>1239--9--3-[2--1--1-]-4--4- PROCESS FOR THE PREPARATION OF 1239-TETRAHYDRO-9-METHYL-3-[2-METHYL-1H-IMIDAZOL-1-YLMETHYL]-4H-CARBAZOL-4-ONE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF</title><date>2002-05-25</date><risdate>2002</risdate><abstract>PURPOSE: Provided is a novel manufacturing method of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl))-4H-carbazol-4-on or its pharmaceutically acceptable salt in higher yield and purity than conventional methods. CONSTITUTION: The manufacturing method is characterized by reacting 1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-on of the formula(2) with 2-methylimidazole derivative of the formula(3) in a mixed solvent of organic solvent and water at room temperature to 150 deg.C fro 2-12 hours to manufacture 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl))-4H-carbazol-4-on of the formula(1) or its pharmaceutically acceptable salt.
본 발명은 할로실란 화합물 존재하에서 하기 화학식 2의 1,2,3,9-테트라히드로-9-메틸-4H-카바졸-4-온을 화학식 3의 2-메틸이미다졸 유도체와 유기용매 또는 유기용매와 물의 혼합용매 중에서 반응시키는 것을 특징으로 하는, 화학식 1의 1,2,3,9-테트라히드로-9-메틸-3-[(2-메틸-1H-이미다졸-1-일)메틸]-4H-카바졸-4-온 또는 그의 약제학적으로 허용가능한 염의 제조 방법에 관한 것으로, 본 발명의 방법에 따르면 보다 간단한 공정으로 목적 화합물을 고수율, 고순도로 제조할 수 있다. 상기 식에서, R은 N,N-디메틸아미노, N,N-디에틸아미노, N,N-디프로필아미노, 몰포린-4-일, 피페리딘-1-일 또는 피롤리딘-1-일이다.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| title | 1239--9--3-[2--1--1-]-4--4- PROCESS FOR THE PREPARATION OF 1239-TETRAHYDRO-9-METHYL-3-[2-METHYL-1H-IMIDAZOL-1-YLMETHYL]-4H-CARBAZOL-4-ONE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF |
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