COMPOSITION CONTAINING L-2-OXOTHIAZOLIDINE- 4-CARBOXYLIC ACID USEFUL FOR TREATMENT OF DIABETES

COMPOSITION CONTAINING L-2-OXOTHIAZOLIDINE- 4-CARBOXYLIC ACID USEFUL FOR TREATMENT OF DIABETES

PURPOSE: The composition containing L-2-oxothiazolidine- 4-carboxylic acid is provided which is useful for the treatment of diabetes. CONSTITUTION: The composition containing L-2-oxothiazolidine- 4-carboxylic acid as an active ingredient is provided which improves the secretion of insulin from pancr...

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Hauptverfasser: SHIN, YEONG MI, JANG, SEON IL, KIM, SE JIN, KIM, U HYEON, PARK, GEUM JAE, PARK, GWANG HYEON, HAN, MYEONG GWAN
Format: Patent
Sprache:eng ; kor
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:PURPOSE: The composition containing L-2-oxothiazolidine- 4-carboxylic acid is provided which is useful for the treatment of diabetes. CONSTITUTION: The composition containing L-2-oxothiazolidine- 4-carboxylic acid as an active ingredient is provided which improves the secretion of insulin from pancreas beta-cells separated from mouse, decreases the concentration of sugar in blood and activates the secretion of insulin when administered into a mouse suffering from the second type of diabetes(C57BL/KsJ-db/db Jcl), wherein the second type of diabetes is non-insulin dependent diabetes millitus(NIDDM). When the second type of composition for the treatment of NIDDM is orally administered into a patient, it contains L-2-oxothiazolidine- 4-carboxylic acid in an amount of 3 to 300 mg/kg.