METHOD FOR PRODUCING CRYSTALLINE CEFUROXIME AXETIL ESTER

PURPOSE: A method for producing crystalline Cefuroxime axe til ester is provided for mass-producing effectively and safely high purity crystalline cefuroxime axetil ester in higher yield. CONSTITUTION: The crystalline cefuroxime axetil ester having about 1:1 of R:S isomer ratio, is produced from the...

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Hauptverfasser:	KANG, SIN UK, LIM, DONG GWON, HAN, GEUM SU, KWON, YUN JA, PARK, DONG CHEOL
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	PURPOSE: A method for producing crystalline Cefuroxime axe til ester is provided for mass-producing effectively and safely high purity crystalline cefuroxime axetil ester in higher yield. CONSTITUTION: The crystalline cefuroxime axetil ester having about 1:1 of R:S isomer ratio, is produced from the reaction solution containing cefuroxime axetil ester by using a first solvent selected from acetic acid ethyl, acetic acid methyl or isopropanol alcohol and a second solvent of cyclohexene, in which the first solvent is used firstly to crystalize cefuroxime axetil ester then the second solvent is used or the first solvent and the second solvent are used together to crystallize cefuroxime axetil ester, in a ratio of the first solvent to second solvent of 1:1 to 1:3, preferably 1:1.8 to 1:2.5, and the crystallization is performed at 5 to 35deg.C.