PREPARATION METHOD OF ALPHA AMINO ACID AND DERIVATIVE THEREOF COMPRISING PHENYLALANINE AND HOMOPHENYLALANINE, FROM AZIRIDINE

PURPOSE: A preparation method of alpha amino acid and derivative thereof comprising phenylalanine and homophenylalanine, from aziridine is provided which manufactures the same by stereo-selective synthesis method. CONSTITUTION: Various (D)-, and (L)-alphaaminoacids and their derivatives is manufactured from aziridine by stereo-selective synthesis method. The alphaaminoacids comprise phenylalanine, substituted phenylalanine having various substituents, and homophenylalanine having one more carbon chain, and they are used as an intermediate of synthetic chemical products including medical supplies. A preparation method of alpha amino acid and derivative thereof is characterized by comprising the following steps: (i)manufacturing aldehyde of formula (5) by reducing (2R)-£1'-phenylethyl|aziridine-2-carboxylic acid ethylester into DIBAL; (ii)manufacturing aminoalcohol of formula (6) by adding aryllithium or arylmagnesium thereto. The aryl of formula (6) is characterized by one of phenyl, 4-methoxyphenyl, 4-fluorophenyl.