METHOD FOR CRYSTALLIZATION OF ALPHA-l-ASPARTYL-L-PHENYLALANINE METHYL ESTER

METHOD FOR CRYSTALLIZATION OF ALPHA-l-ASPARTYL-L-PHENYLALANINE METHYL ESTER

PURPOSE: Aspartame is prepared by directly blowing cold air which has a good filtrating property and drying property. CONSTITUTION: The 2- 10 weight % concentration of alpha-L-aspartyl-L-phenylalanine methyl ester solution is crystallized at 20- 60°C in water or water-organic solvent such as C1- C3...

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Bibliographische Detailangaben
Hauptverfasser: CHOI, KYUNG EUN, EOM, HEON YONG, DO, HWA JEONG, LIM, BEON SAM
Format: Patent
Sprache:eng ; kor
Schlagworte:
AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUSPOLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE
APPARATUS THEREFOR
CHEMISTRY
CRYSTAL GROWTH
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITHDEFINED STRUCTURE
REFINING BY ZONE-MELTING OF MATERIAL
SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITHDEFINED STRUCTURE
SINGLE-CRYSTAL-GROWTH
UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL ORUNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL
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Beschreibung
Zusammenfassung:PURPOSE: Aspartame is prepared by directly blowing cold air which has a good filtrating property and drying property. CONSTITUTION: The 2- 10 weight % concentration of alpha-L-aspartyl-L-phenylalanine methyl ester solution is crystallized at 20- 60°C in water or water-organic solvent such as C1- C3 alcohol by injection to 0.05- 10 mm size of drop through the cold air layer such as air, nitrogen and inert gas of -5- 50°C. 본 발명은 알파-엘-아스파틸-엘-페닐알라닌 메틸에스테르((α- L- Aspartyl - L- Phenylalanine Methylester, 이하 알파-아스파탐;α-Aspartame; APM 이라 함) 수용액의 결정화에 있어서 고온의 알파-아스파탐 과포화용액을 냉기층에 접촉 및 냉각시켜 결정화하는 방법에 관한 것이다. 본 발명은 알파-아스파탐 용액을 2내지 10wt%농도로 제조하여 분사용기에 담고 외부의 장치로부터 냉기를 직접 결정관 상부로 흐르게 하여 일정한 냉기층을 형성하게 한 후 상기의 용액을 분사시켜 냉각하므로서 양질의 알파-아스파탐 결정을 얻는 방법이다. 알파-아스파탐은 물 또는 물과 혼합된 유기용매를 사용하며 아스파탐의 결정화에 영향을 주지않는 기체를 사용하여 아스파탐 결정관 상부에 냉기층을 형성하도록 하여 종래의 아스파탐 결정화방법에서 나타나는 여과 및 탈수의 문제점을 해결할 수 있는 새로운 아스파탐 결정화 방법이다.