A novel actinoflavosides and the use of thereof

In the present invention, three new secondary metabolites, actinoflavosides were found in a culture solution of two actinobacteria strains (JML48 and JMS33) isolated from Muan tidal flat sediments in Korea, and the planar structure and steric structure of the actinoflavosides were confirmed by MS, U...

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Bibliographische Detailangaben
Hauptverfasser:	YOUNG RAN KIM, KYUHO MOON, HYEONGJU JEONG, SE JIN JO
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY DERIVATIVES THEREOF FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF SUGARS TRAPPING
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Beschreibung
Zusammenfassung:	In the present invention, three new secondary metabolites, actinoflavosides were found in a culture solution of two actinobacteria strains (JML48 and JMS33) isolated from Muan tidal flat sediments in Korea, and the planar structure and steric structure of the actinoflavosides were confirmed by MS, UV and NMR. analysis, DQF-COSY experiment, and modified Mosher method. Actinoflavosides, a new substance identified, exhibited antibacterial activity, significantly increased IL-2 production in mouse spleen cells, reduced IL-4 production and promoted spleen cell proliferation, and thus can be used for effective treatment of cancer or various immune-related diseases as well as antibacterial and bacterial infectious diseases. 본 발명은 대한민국 무안 갯벌 퇴적물에서 분리된 두 가지 방선균 균주(JML48 및 JMS33)의 배양액에서 세 가지 새로운 2차 대사산물인 액티노플라보사이드들을 발견하고 상기 악티노플라보사이드의 평면 구조와 입체 구조는 MS, UV 및 NMR 분석 및 DQF-COSY 실험 및 수정된 Mosher 방법으로 확인하였다. 확인된 새로운 물질인 악티노플라보사이드들은 항균 활성을 나타냈고, 마우스 비장 세포에서 IL-2 생성을 상당히 증가시켰으며 IL-4의 생성은 감소시키고 비장 세포를 증식을 촉진하므로 항균제 및 세균 감염성 질환뿐만 아니라 암 또는 각종 면역 관련 질환에 효과적인 치료 용도로 이용될 수 있다.