E E A NOVEL EPITOPE OF IMMUNOGLOBULIN E ANTIBODY BINDING THERETO AND A KIT COMPRISING ABOVE ANTIBODY FOR ANALYSIS OF IMMUNOGLOBULIN E

The present invention relates to a peptide formed of the amino acid sequence of SEQ ID NO: 3, which is a novel epitope of immunoglobulin E (IgE), and to an anti-IgE antibody binding to the peptide. The peptide and the antibody may be used to diagnose allergic diseases or to investigate therapeutic a...

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Bibliographische Detailangaben
Hauptverfasser:	PARK EUN YOUNG, HONG KWANG WON, JANG HA KYUNG, KIM BONG HUI
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
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Beschreibung
Zusammenfassung:	The present invention relates to a peptide formed of the amino acid sequence of SEQ ID NO: 3, which is a novel epitope of immunoglobulin E (IgE), and to an anti-IgE antibody binding to the peptide. The peptide and the antibody may be used to diagnose allergic diseases or to investigate therapeutic agents for allergic diseases. Further, the present invention relates to a kit for analyzing IgE in a sample containing the antibody, and to a diagnostic method for allergic diseases using the kit. Accordingly, the present invention allows typical inhaled or food-related allergies that most frequently occur in the Korean population to be qualitatively analyzed, and further allows allergies to be diagnosed shortly after blood sampling. 신규한 면역글로불린 E(Immunoglobulin E: IgE)의 에피토프(epitope)인 서열번호 3의 아미노산 서열로 이루어진 펩티드, 상기 펩티드에 결합하는 항 면역글로불린 E 항체에 관한 것으로, 상기 펩티드 및 항체를 알레르기 질환의 진단 또는 치료제 연구 등에 활용할 수 있다. 또한, 상기 항체를 포함하는 시료 중 면역글로불린 E을 분석하기 위한 키트 및 상기 키트를 이용한 알레르기 질환의 진단방법에 관한 것으로, 한국인에게서 발생 빈도가 높은 대표적인 흡입성, 음식 알레르기의 유무를 정성분석 가능하며, 채혈 후 빠른 시간 내에 알레르기를 진단할 수 있다.