Recombinant fibrinolytic protease from Vibrio furnissii and uses thereof

The present invention relates to a recombinant thrombolytic enzyme derived from Vibrio furnissii, a composition for thrombolysis comprising the recombinant thrombolytic enzyme as an active ingredient, a method for decomposing thrombus by treating the composition with an object containing thrombus, a...

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Bibliographische Detailangaben
Hauptverfasser:	CHO, YEONG HEE, AHN, CHEOL, PARK, JUNG EUN, LIM, GA EUN, LIM, DO SUNG, LEE, JUNG SUP
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a recombinant thrombolytic enzyme derived from Vibrio furnissii, a composition for thrombolysis comprising the recombinant thrombolytic enzyme as an active ingredient, a method for decomposing thrombus by treating the composition with an object containing thrombus, a method for producing a recombinant thrombolytic enzyme using a recombinant microorganism transformed with a recombinant vector comprising a gene encoding the recombinant thrombolytic enzyme, the recombinant thrombolytic enzyme produced by the method, a health food composition and a pharmaceutical composition for preventing or ameliorating thrombosis comprising the recombinant thrombolytic enzyme as an active ingredient. The recombinant thrombolytic enzyme of the present invention may be effectively used for the treatment and prevention of thrombosis or similar diseases. 본 발명은 비브리오 프루니씨() 유래의 재조합 혈전분해 효소, 상기 재조합 혈전분해 효소를 유효성분으로 함유하는 혈전분해용 조성물, 상기 조성물을 혈전을 포함하고 있는 개체에 처리하여 혈전을 분해하는 방법, 상기 재조합 혈전분해 효소를 코딩하는 유전자를 포함하는 재조합 벡터로 형질전환된 재조합 미생물을 이용하여 재조합 혈전분해 효소를 생산하는 방법, 상기 방법에 의해 생산된 재조합 혈전분해 효소, 상기 재조합 혈전분해 효소를 유효성분으로 포함하는 혈전증의 예방 또는 개선용 건강기능식품 조성물 및 약학 조성물에 관한 것으로, 본 발명의 재조합 혈전분해 효소는 혈전증 또는 이와 유사한 질환의 치료 및 예방에 효과적으로 활용될 수 있을 것이다.