A ANTI-INFLAMATORY COMPOSITION CONTAINING GRISEUSRAZIN A

The present invention relates to an anti-inflammatory composition comprising griseurazin A as an active ingredient. The griseurazin A contained as the active ingredient of the composition of the present invention is a pyrazine derivative compound isolated from a marine organism-derived fungus, The g...

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Bibliographische Detailangaben
Hauptverfasser:	YOON, CHI SU, JUNG, YONG TAEK, YOON, JUNG HOON, KIM, YOUN CHUL, LEE, DONG SUNG, OH, HYUN CHEOL
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Beschreibung
Zusammenfassung:	The present invention relates to an anti-inflammatory composition comprising griseurazin A as an active ingredient. The griseurazin A contained as the active ingredient of the composition of the present invention is a pyrazine derivative compound isolated from a marine organism-derived fungus, The griseurazin A has an excellent anti-inflammatory effects for inhibiting inflammatory reactions in mouse-derived macrophages, and increases activities and expression of heme oxygenase-1 (HO-1) which is an enzyme closely related to a cell protection mechanism. Since substances derived from nature with low possibility of side effects owing to stability are used, the griseurazin A can be useful for treating, ameliorating, or preventing inflammation-related inflammatory diseases. 본 발명은 그리세우스라진 A를 유효성분으로 포함하는 항염 조성물에 관한 것으로, 본 발명의 조성물의 유효성분인 그리세우스라진 A는 해양생물 유래 진균으로부터 분리한 피라진(pyrazine) 유도체 화합물로, 상기 그리세우스라진 A는 마우스 유래 대식세포에서의 염증 반응을 억제하는 항염증 효과가 우수하고, 세포보호 기전과 밀접하게 관련되어 있는 효소인 헤마틴 산화효소-1(Heme Oxygenase-1, HO-1)의 발현과 활성을 증가시킬 뿐만 아니라, 안정성이 인정되어 부작용 발생 가능성이 낮은 천연물 유래 물질을 이용하는 것이므로, 염증 관련 염증질환의 치료, 개선 또는 예방을 위해 유용하게 이용될 수 있다.