B COMPOSITION FOR TREATING OR PREVENTING NEURODEGENERATIVE DISEASE CONTAINING EXTRACT OF FUMITREMORGIN B

The present invention relates to an anti-inflammatory composition comprising fumitremorgin B separated from SF-5497, which is fungus derived from both the North and the South poles, as an active ingredient. The composition of the present invention shows an excellent anti-inflammatory effect in a mou...

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Bibliographische Detailangaben
Hauptverfasser:	KIM, KWAN WOO, YOON, CHI SU, KO, WON MIN, KIM, YOUN CHUL, OH, HYUN CHEOL, SOHN, JAE HAK
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Beschreibung
Zusammenfassung:	The present invention relates to an anti-inflammatory composition comprising fumitremorgin B separated from SF-5497, which is fungus derived from both the North and the South poles, as an active ingredient. The composition of the present invention shows an excellent anti-inflammatory effect in a mouse-derived brain cell, and thus can be useful as a medical composition and a cosmetic composition for preventing, alleviating, and treating brain inflammation-related diseases. In particular, the fumitremorgin B derived from a natural material does not have cytotoxicity, and thus safety is acknowledged. Also, as a result of an experiment using a mouse-derived microglial cell, it has been confirmed that expression and activities of hematin oxygenase-1 (heme oxygenase-1) known as an enzyme closely related to a cell protecting mechanism are improved and an excellent effect of inhibiting cell inflammation is ensured. Accordingly, the anti-inflammatory composition including the same as an active ingredient can be applied as an anti-inflammatory agent for inhibiting inflammation in diseases related to inflammation, a cosmetic composition having an antiinflammation effect, and the like. 본 발명은 양극해 해양생물 유래 진균인 SF-5497에서 분리한 푸미트레모르진 B를 유효성분으로 포함하는 항염 조성물에 관한 것으로, 본 발명의 조성물은 마우스 유래 뇌세포에서 뛰어난 항염증 효과를 나타내므로, 뇌 염증 관련 질환의 예방, 개선 및 치료를 위한 의약 조성물 및 화장료 조성물로 유용하게 이용될 수 있다. 구체적으로, 상기 천연물로부터 유래된 푸미트레모르진 B는 세포 독성이 없어, 안전성이 인정될 뿐만 아니라, 마우스 유래 미세아교세포를 이용한 실험 결과, 세포보호기전과 밀접하게 관련되어 있는 효소로 알려진 헤마틴 산화효소-1(Heme Oxygenase-1, HO-1)의 발현과 활성을 증가시키며, 세포 염증반응을 억제하는 효과가 우수한 것으로 확인되었으므로, 이를 유효성분으로 포함하는 상기 항염 조성물은 염증과 관련된 질병에서 염증을 억제하는 항염증제 및 항염효과가 있는 화장료 조성물 등으로 응용될 수 있다.