NANOPARTICLE CONJUGATED WITH CETUXIMAB AND MANUFACTURING METHOD THEREOF
A nanoparticle conjugated with a cetuximab antibody is provided to obtain a contrast medium for in vitro and in vivo imaging of tissues with colon cancer, and to inhibit growth of colon cancer. A nanoparticle for diagnosis of colon cancer comprises: a core particle formed of a magnetic material; a s...
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| creator | JANG, EUE SOON CHO, YOUNG SEOK YOON, TAE JONG KONG, KYUNG TAE CHAE, ZOO HYUN CHOI, BONG KEUN RO, JU YOUNG CHOI, EUN JEONG CHANG, KI YUK YI, GYU CHUL AHN, CHE HONG |
| description | A nanoparticle conjugated with a cetuximab antibody is provided to obtain a contrast medium for in vitro and in vivo imaging of tissues with colon cancer, and to inhibit growth of colon cancer. A nanoparticle for diagnosis of colon cancer comprises: a core particle formed of a magnetic material; a silica compound shell containing an organic fluorescent material; and a cetuximab antibody bonded to the shell surface by way of an NHS-PEO12-maleimide group. In the nanoparticle, the magnetic core particle is at least one oxide selected from the group consisting of cobalt, iron, manganese, zinc, nickel and copper. Further, the organic fluorescent material is one of an RITC(Rhodamine B isothiocyanate) and an FITC(fluoresceine isothiocyanate). |
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A nanoparticle for diagnosis of colon cancer comprises: a core particle formed of a magnetic material; a silica compound shell containing an organic fluorescent material; and a cetuximab antibody bonded to the shell surface by way of an NHS-PEO12-maleimide group. In the nanoparticle, the magnetic core particle is at least one oxide selected from the group consisting of cobalt, iron, manganese, zinc, nickel and copper. 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A nanoparticle for diagnosis of colon cancer comprises: a core particle formed of a magnetic material; a silica compound shell containing an organic fluorescent material; and a cetuximab antibody bonded to the shell surface by way of an NHS-PEO12-maleimide group. In the nanoparticle, the magnetic core particle is at least one oxide selected from the group consisting of cobalt, iron, manganese, zinc, nickel and copper. Further, the organic fluorescent material is one of an RITC(Rhodamine B isothiocyanate) and an FITC(fluoresceine isothiocyanate).</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | MANUFACTURE OR TREATMENT THEREOF NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS,MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES ASDISCRETE UNITS NANOTECHNOLOGY PERFORMING OPERATIONS TRANSPORTING |
| title | NANOPARTICLE CONJUGATED WITH CETUXIMAB AND MANUFACTURING METHOD THEREOF |
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