NANOPARTICLE CONJUGATED WITH CETUXIMAB AND MANUFACTURING METHOD THEREOF

A nanoparticle conjugated with a cetuximab antibody is provided to obtain a contrast medium for in vitro and in vivo imaging of tissues with colon cancer, and to inhibit growth of colon cancer. A nanoparticle for diagnosis of colon cancer comprises: a core particle formed of a magnetic material; a s...

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Bibliographische Detailangaben
Hauptverfasser:	JANG, EUE SOON, CHO, YOUNG SEOK, YOON, TAE JONG, KONG, KYUNG TAE, CHAE, ZOO HYUN, CHOI, BONG KEUN, RO, JU YOUNG, CHOI, EUN JEONG, CHANG, KI YUK, YI, GYU CHUL, AHN, CHE HONG
Format:	Patent
Sprache:	eng
Schlagworte:	MANUFACTURE OR TREATMENT THEREOF NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS,MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES ASDISCRETE UNITS NANOTECHNOLOGY PERFORMING OPERATIONS TRANSPORTING
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Beschreibung
Zusammenfassung:	A nanoparticle conjugated with a cetuximab antibody is provided to obtain a contrast medium for in vitro and in vivo imaging of tissues with colon cancer, and to inhibit growth of colon cancer. A nanoparticle for diagnosis of colon cancer comprises: a core particle formed of a magnetic material; a silica compound shell containing an organic fluorescent material; and a cetuximab antibody bonded to the shell surface by way of an NHS-PEO12-maleimide group. In the nanoparticle, the magnetic core particle is at least one oxide selected from the group consisting of cobalt, iron, manganese, zinc, nickel and copper. Further, the organic fluorescent material is one of an RITC(Rhodamine B isothiocyanate) and an FITC(fluoresceine isothiocyanate).