A PREPARATION METHOD OF 2-[(4-BROMOMETHYL)PHENYL]PROPIONIC ACID

A method for preparing 2-[(4-bromomethyl)phenyl]propionic acid is provided to produce high-purity 2-[(4-bromomethyl)phenyl]propionic acid used as a main intermediate in the production of phenylpropionic acid-based anti-inflammatory drugs in an industrially efficient manner. A method for preparing 2-...

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Bibliographische Detailangaben
Hauptverfasser:	KIM, BYUNG HWAN, KOO, EON CHEOL, CHO, YANG RAI, JEONG, SEON YI, JI, GI HWAN, SHIM, YOUNG JI
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY METALLURGY ORGANIC CHEMISTRY
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Zusammenfassung:	A method for preparing 2-[(4-bromomethyl)phenyl]propionic acid is provided to produce high-purity 2-[(4-bromomethyl)phenyl]propionic acid used as a main intermediate in the production of phenylpropionic acid-based anti-inflammatory drugs in an industrially efficient manner. A method for preparing 2-[(4-bromomethyl)phenyl]propionic acid includes the steps of: adding bromic acid and hydrogen peroxide to brominate 2-(4-methylphenyl)propionic acid at 0-80 ‹C in the presence of an organic solvent; and further re-crystallizing the obtained 2-[(4-bromomethyl)phenyl]propionic acid in the presence of a solvent. The bromic acid and hydrogen peroxide are used in amounts of 1-1.5 equivalents based on the 2-(4-methylphenyl)propionic acid, respectively.