PROCESS FOR PREPARING CHIRAL SUBSTITUTED CYCLOPROPANE CARBOXAMIDE
Provided is a method for preparing a chiral substituted cyclopropane carboxamide, which avoids a need for expensive chiral separating agent, such as a chiral amine or L-menthol, or a complicated fermentation step, produces the target product with high optical purity and yield, and is cost-efficient....
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| creator | YOO, JI SANG KIM, JI SHICK SON, JAE MIN ROH, KYOUNG ROK JANG, JONG WON |
| description | Provided is a method for preparing a chiral substituted cyclopropane carboxamide, which avoids a need for expensive chiral separating agent, such as a chiral amine or L-menthol, or a complicated fermentation step, produces the target product with high optical purity and yield, and is cost-efficient. The method for preparing a chiral substituted cyclopropane carboxamide comprises the steps of: (1) reacting racemic cyclopropane carboxylate represented by the following formula 3 with lipase derived from Candida antarctica in an organic solvent in which ammonia gas is dissolved at a predetermined reaction temperature; and (2) separating (S)-cyclopropane carboxamide compound represented by the following formula 1 from (R)-cyclopropane carboxamide compound represented by the following formula 2. |
| format | Patent |
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The method for preparing a chiral substituted cyclopropane carboxamide comprises the steps of: (1) reacting racemic cyclopropane carboxylate represented by the following formula 3 with lipase derived from Candida antarctica in an organic solvent in which ammonia gas is dissolved at a predetermined reaction temperature; and (2) separating (S)-cyclopropane carboxamide compound represented by the following formula 1 from (R)-cyclopropane carboxamide compound represented by the following formula 2.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; BEER ; BIOCHEMISTRY ; CHEMISTRY ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2006</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20061121&DB=EPODOC&CC=KR&NR=100650797B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20061121&DB=EPODOC&CC=KR&NR=100650797B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YOO, JI SANG</creatorcontrib><creatorcontrib>KIM, JI SHICK</creatorcontrib><creatorcontrib>SON, JAE MIN</creatorcontrib><creatorcontrib>ROH, KYOUNG ROK</creatorcontrib><creatorcontrib>JANG, JONG WON</creatorcontrib><title>PROCESS FOR PREPARING CHIRAL SUBSTITUTED CYCLOPROPANE CARBOXAMIDE</title><description>Provided is a method for preparing a chiral substituted cyclopropane carboxamide, which avoids a need for expensive chiral separating agent, such as a chiral amine or L-menthol, or a complicated fermentation step, produces the target product with high optical purity and yield, and is cost-efficient. 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The method for preparing a chiral substituted cyclopropane carboxamide comprises the steps of: (1) reacting racemic cyclopropane carboxylate represented by the following formula 3 with lipase derived from Candida antarctica in an organic solvent in which ammonia gas is dissolved at a predetermined reaction temperature; and (2) separating (S)-cyclopropane carboxamide compound represented by the following formula 1 from (R)-cyclopropane carboxamide compound represented by the following formula 2.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY SPIRITS VINEGAR WINE |
| title | PROCESS FOR PREPARING CHIRAL SUBSTITUTED CYCLOPROPANE CARBOXAMIDE |
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