PROCESS FOR PREPARING CHIRAL SUBSTITUTED CYCLOPROPANE CARBOXAMIDE

Provided is a method for preparing a chiral substituted cyclopropane carboxamide, which avoids a need for expensive chiral separating agent, such as a chiral amine or L-menthol, or a complicated fermentation step, produces the target product with high optical purity and yield, and is cost-efficient....

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Bibliographische Detailangaben
Hauptverfasser:	YOO, JI SANG, KIM, JI SHICK, SON, JAE MIN, ROH, KYOUNG ROK, JANG, JONG WON
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided is a method for preparing a chiral substituted cyclopropane carboxamide, which avoids a need for expensive chiral separating agent, such as a chiral amine or L-menthol, or a complicated fermentation step, produces the target product with high optical purity and yield, and is cost-efficient. The method for preparing a chiral substituted cyclopropane carboxamide comprises the steps of: (1) reacting racemic cyclopropane carboxylate represented by the following formula 3 with lipase derived from Candida antarctica in an organic solvent in which ammonia gas is dissolved at a predetermined reaction temperature; and (2) separating (S)-cyclopropane carboxamide compound represented by the following formula 1 from (R)-cyclopropane carboxamide compound represented by the following formula 2.