SOLID DISPERSION COMPRISING TACROLIMUS AND ENTERIC-COATED MACROMOLECULE

SOLID DISPERSION COMPRISING TACROLIMUS AND ENTERIC-COATED MACROMOLECULE

This invention relates to a solid dispersion formulation comprising tacrolimus and enteric polymer. The solid dispersion formulation may contribute to better stability of tacrolimus preparation under high temperature and humidity condition through reduced recrystallization rate of tacrolimus. In add...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WANG, HUN SIK, YEOM, DAE IL, PARK, JUN SANG, SONG, WOO HEON
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:This invention relates to a solid dispersion formulation comprising tacrolimus and enteric polymer. The solid dispersion formulation may contribute to better stability of tacrolimus preparation under high temperature and humidity condition through reduced recrystallization rate of tacrolimus. In addition, the solid dispersion formulation releases tacrolimus immediately in aqueous media and elevated solubility level maintains for certain period of time and that way the formulation may also enhance the bioavailability and oral absorption rate of tacrolimus.