ANTI-TUMOR LIGNAN COMPOUND ISOLATED FROM ANTHRISCUS SYLVESTRIS HOFFMANN(UMBELLIFERAE)
PURPOSE: An anti-tumor lignan compound isolated from Anthriscus sylvestris HOFFMANN(Umbelliferae) is provided, which compound has similar or improved anti-tumor activity to the prior anti-tumor compounds and no toxicity. CONSTITUTION: The anti-tumor lignan compound isolated from Anthriscus sylvestri...
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| Zusammenfassung: | PURPOSE: An anti-tumor lignan compound isolated from Anthriscus sylvestris HOFFMANN(Umbelliferae) is provided, which compound has similar or improved anti-tumor activity to the prior anti-tumor compounds and no toxicity. CONSTITUTION: The anti-tumor lignan compound isolated from Anthriscus sylvestris HOFFMANN(Umbelliferae) represented by formula (1) is provided. The method for isolating the Anti-tumor lignan compound isolated from Anthriscus sylvestris HOFFMANN(Umbelliferae) of formula (1) comprises the steps of: cutting roots of Anthriscus sylvestris HOFFMANN(Umbelliferae); extracting the cut roots of Anthriscus sylvestris HOFFMANN(Umbelliferae) with methanol in 5 times; fractioning the methanol extract of Anthriscus sylvestris HOFFMANN(Umbelliferae) with solvent of hexane, chloroform, acetic acid ethyl, butanol and water to obtain an active fraction; subjecting the active fraction to silica gel, Sephadex and RP-18 chromatography to obtain anti-tumor compounds; and isolating and purifying an anti-tumor compound, Angeloyl podophyllotoxin, by subjecting the anti-tumor compounds to prep HPLC. |
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