VINYL-PYRROLIDINONE CEPHALOSPORINS

PURPOSE: Provided are cephalosporin derivatives of the formula(1), and their manufacturing method and use as pharmaceutically active substances, particularly for the treatment and prophylaxis of infectious diseases. CONSTITUTION: A cephalosporin derivative is represented by the formula(1), wherein X...

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Bibliographische Detailangaben
Hauptverfasser:	PAGE MALCOLM, ANGEHRN PETER, HEINZE-KRAUSS INGRID, HEBEISEN PAUL, RUNTZ VALERIE
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PURPOSE: Provided are cephalosporin derivatives of the formula(1), and their manufacturing method and use as pharmaceutically active substances, particularly for the treatment and prophylaxis of infectious diseases. CONSTITUTION: A cephalosporin derivative is represented by the formula(1), wherein X is CH or N; R¬1 is hydrogen or cyclopentyl; R¬2 is selected from the group consisting of formulae; R¬3 is hydrogen, an alkalimetal ion or a tertiary ammonium group; R¬4 is hydrogen, an amino protecting group, pyrrolidin-2-ylmethyl, azetidin-3-ylmethyl, iminomethyl, or 1-carbamimidoyl; R¬5 is hydrogen, dialkylcarbamoyl, .omega.-hydroxyalkyl, .omega.-aminoalkyl, 1-hydroxy-3-aminomethyl-propyl or (hydroxy)-(pyrrolidin-2-yl)methyl; R¬6 is hydrogen, trifluoromethyl or hydroxy; and R¬7 is alkyl, .omega.-hydroxy-alkyl, cycloalkyl, 3-pyrrolidinyl, 3-azetidinyl, iminomethyl or 1-carbamimidoyl.