METHOD OF SYNTHESIS FOR 6,9-BIS((2-AMINOETHYL)AMINO)BENZO(G)ISOQUINOLINE-5, 10-DIONE AND ITS DIMALEATE SALT
본 발명은 안드로겐-의존성의, 특히 전립선암을 치료하는데에 유용한, 유리 염기 또는 약제학적으로 허용될 수 있는 염으로서의 하기 일반식(3)의 화합물에 관한 것이다 : 상기 식에서, R및 R는 각각 수소 또는 C-C-알킬을 나타내고, A는 -O- 또는 -CRR를 나타내며, 여기에서 R및 R는 R또는 R에 대해 정의한 바와 같고, R는 아다만틸기를 나타내며, Py는 3- 또는 4-피리딜기를 나타낸다. In the search for novel heteroanalogs of anthracendiones, 6,9-bis[(2-aminoe...
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| creator | DIDOMENICO, ROBERTO SPINELLI, SILVANO |
| description | 본 발명은 안드로겐-의존성의, 특히 전립선암을 치료하는데에 유용한, 유리 염기 또는 약제학적으로 허용될 수 있는 염으로서의 하기 일반식(3)의 화합물에 관한 것이다 : 상기 식에서, R및 R는 각각 수소 또는 C-C-알킬을 나타내고, A는 -O- 또는 -CRR를 나타내며, 여기에서 R및 R는 R또는 R에 대해 정의한 바와 같고, R는 아다만틸기를 나타내며, Py는 3- 또는 4-피리딜기를 나타낸다.
In the search for novel heteroanalogs of anthracendiones, 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione dimaleate salt (BBR 2778), was selected as the most promising compound. New methods of synthesis produce the compound in purity greater than 99%. |
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In the search for novel heteroanalogs of anthracendiones, 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione dimaleate salt (BBR 2778), was selected as the most promising compound. New methods of synthesis produce the compound in purity greater than 99%.</description><edition>6</edition><language>eng ; kor</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1999</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19991015&DB=EPODOC&CC=KR&NR=100224153B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19991015&DB=EPODOC&CC=KR&NR=100224153B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DIDOMENICO, ROBERTO</creatorcontrib><creatorcontrib>SPINELLI, SILVANO</creatorcontrib><title>METHOD OF SYNTHESIS FOR 6,9-BIS((2-AMINOETHYL)AMINO)BENZO(G)ISOQUINOLINE-5, 10-DIONE AND ITS DIMALEATE SALT</title><description>본 발명은 안드로겐-의존성의, 특히 전립선암을 치료하는데에 유용한, 유리 염기 또는 약제학적으로 허용될 수 있는 염으로서의 하기 일반식(3)의 화합물에 관한 것이다 : 상기 식에서, R및 R는 각각 수소 또는 C-C-알킬을 나타내고, A는 -O- 또는 -CRR를 나타내며, 여기에서 R및 R는 R또는 R에 대해 정의한 바와 같고, R는 아다만틸기를 나타내며, Py는 3- 또는 4-피리딜기를 나타낸다.
In the search for novel heteroanalogs of anthracendiones, 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione dimaleate salt (BBR 2778), was selected as the most promising compound. New methods of synthesis produce the compound in purity greater than 99%.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1999</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNisEKgkAUAL10iOofHnRRcMHVDDruts98pLvkbge7iMR2KUqw_yeJPqDTDMPMg3uNrjQKTAG21a5ESxYK08A23jFJNgxTJmrSZtraKvpqJFFfTHiIyJrTeQoVaWR5DDxhioxGEFoBOQuKalGhcAhWVG4ZzG79Y_SrHxfBukC3L5kfXp0fh_7qn_7dHRueJGm64XkmJc_-uz775DYz</recordid><startdate>19991015</startdate><enddate>19991015</enddate><creator>DIDOMENICO, ROBERTO</creator><creator>SPINELLI, SILVANO</creator><scope>EVB</scope></search><sort><creationdate>19991015</creationdate><title>METHOD OF SYNTHESIS FOR 6,9-BIS((2-AMINOETHYL)AMINO)BENZO(G)ISOQUINOLINE-5, 10-DIONE AND ITS DIMALEATE SALT</title><author>DIDOMENICO, ROBERTO ; SPINELLI, SILVANO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR100224153BB13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>1999</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>DIDOMENICO, ROBERTO</creatorcontrib><creatorcontrib>SPINELLI, SILVANO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DIDOMENICO, ROBERTO</au><au>SPINELLI, SILVANO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD OF SYNTHESIS FOR 6,9-BIS((2-AMINOETHYL)AMINO)BENZO(G)ISOQUINOLINE-5, 10-DIONE AND ITS DIMALEATE SALT</title><date>1999-10-15</date><risdate>1999</risdate><abstract>본 발명은 안드로겐-의존성의, 특히 전립선암을 치료하는데에 유용한, 유리 염기 또는 약제학적으로 허용될 수 있는 염으로서의 하기 일반식(3)의 화합물에 관한 것이다 : 상기 식에서, R및 R는 각각 수소 또는 C-C-알킬을 나타내고, A는 -O- 또는 -CRR를 나타내며, 여기에서 R및 R는 R또는 R에 대해 정의한 바와 같고, R는 아다만틸기를 나타내며, Py는 3- 또는 4-피리딜기를 나타낸다.
In the search for novel heteroanalogs of anthracendiones, 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione dimaleate salt (BBR 2778), was selected as the most promising compound. New methods of synthesis produce the compound in purity greater than 99%.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | METHOD OF SYNTHESIS FOR 6,9-BIS((2-AMINOETHYL)AMINO)BENZO(G)ISOQUINOLINE-5, 10-DIONE AND ITS DIMALEATE SALT |
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