AMINOCARBONYLCARBAMATES RELATED TO PHYSOSTIGMINE A PROCESS FOR THEIR PREPARATION

콜린성 기능을 향상시키고 진통제로서 유용한 일반식(Ⅰ)의 피소스티그민과 관련된 각종 유도체가 기술된다. 상기식에서, Z, R및 R는 명세서에서 정의한 바와 동일하다. The present invention relates to various derivatives related to physostigmine of the formula I where Z is hydrogen, halogen or loweralkyl; R1 is loweralkyl, cycloalkyl or aryl; and R2 is loweralkyl or cycloa...

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Bibliographische Detailangaben
Hauptverfasser:	HAMER, RUSSELL RICHARD LEE, GLAMKOWSKI, EDWARD JOSEPH, CHIANG, YULIN
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	콜린성 기능을 향상시키고 진통제로서 유용한 일반식(Ⅰ)의 피소스티그민과 관련된 각종 유도체가 기술된다. 상기식에서, Z, R및 R는 명세서에서 정의한 바와 동일하다. The present invention relates to various derivatives related to physostigmine of the formula I where Z is hydrogen, halogen or loweralkyl; R1 is loweralkyl, cycloalkyl or aryl; and R2 is loweralkyl or cycloalkyl; the 3aS-cis isomer or the 3aR-isomer thereof or a mixture of the two isomers including the racemic mixture, or a pharmaceutically acceptable acid addition salt thereof, and a process for their preparation. The compounds according to the invention are useful for enhancing cholinergic function, and as analgesic agents.