A METHOD AND INTERMEDIATES FOR THE PREPARATION OF 6-FLUOROBENZISOTHIAZOLES

본 발명은 2-플루오로펜아실 화합물로부터 6-플루오로-1,2-벤즈이소티아졸을 제조하는 방법 및 이 방법에 유용한 중간체 화합물에 관한 것이다. A process for the preparation of 6-fluoro-1,2-benzisothiazoles of formula I where R is hydrogen, loweralkyl, cycloalkyl, aralkyl, aryl, or a group of the formulae -CO R , -CN or -C(=O)R; R is alkyl or aryl; k, m, m, n and n are independently integers from 1 to 4; which comprises a) reacting a compound of the formula III wherein R is as defined above and R is hydrogen, loweralkyl, or arylloweralkyl, with a halogenating agent to obtain a compound of the formula IV wherein R is as defined and Hal is halogen, and b) reacting the compound of formula IV as obtained in step a) with ammonia. s