ELASTASE INHIBITOR FROM KOREAN HIRUDO NIPPONIA

An elastase-inhibiting protein which has the following amino acid sequence: VDENAEDTHGLCGEKTCSPAQVCLNNECACTAIRCMIFCPNGFKVDENGCEYPCTCA is useful in the treatment of diseases associated with an excess level of elastase such as rheumatoid arthritis, emphysema and psoriasis. The protein may be extracted...

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Hauptverfasser: JUNG, HYO-ILL, LEE, JOO-YUN, KANG, KYE-WON, KIM, DONG-RYUNG, HONG, SUK-JIN
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creator JUNG, HYO-ILL
LEE, JOO-YUN
KANG, KYE-WON
KIM, DONG-RYUNG
HONG, SUK-JIN
description An elastase-inhibiting protein which has the following amino acid sequence: VDENAEDTHGLCGEKTCSPAQVCLNNECACTAIRCMIFCPNGFKVDENGCEYPCTCA is useful in the treatment of diseases associated with an excess level of elastase such as rheumatoid arthritis, emphysema and psoriasis. The protein may be extracted from an acetone extract of the leech, Hirudo ripponia , followed by, sequentially, gel filtration chromatography, anion-exchange chromatography and HPLC.
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title ELASTASE INHIBITOR FROM KOREAN HIRUDO NIPPONIA
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