ELASTASE INHIBITOR FROM KOREAN HIRUDO NIPPONIA

An elastase-inhibiting protein which has the following amino acid sequence: VDENAEDTHGLCGEKTCSPAQVCLNNECACTAIRCMIFCPNGFKVDENGCEYPCTCA is useful in the treatment of diseases associated with an excess level of elastase such as rheumatoid arthritis, emphysema and psoriasis. The protein may be extracted...

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Bibliographische Detailangaben
Hauptverfasser:	JUNG, HYO-ILL, LEE, JOO-YUN, KANG, KYE-WON, KIM, DONG-RYUNG, HONG, SUK-JIN
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	An elastase-inhibiting protein which has the following amino acid sequence: VDENAEDTHGLCGEKTCSPAQVCLNNECACTAIRCMIFCPNGFKVDENGCEYPCTCA is useful in the treatment of diseases associated with an excess level of elastase such as rheumatoid arthritis, emphysema and psoriasis. The protein may be extracted from an acetone extract of the leech, Hirudo ripponia , followed by, sequentially, gel filtration chromatography, anion-exchange chromatography and HPLC.