PROCESS FOR PREPARING OF ÑÔ-METHYLAZETIDINONE DERIVATIVE

(3S,4S)-3{(1R)-1-[(t-Butyldimethylsillyl)oxy ethyl}-4-{[(1R)-1-methyl-(4,4-dialkyl-2-thioxo-1,3-oxaorthiazolidine)-3)-yl methyl}azethidine-2-one(II), useful as an intermediate in manufacturing 1-beta-methylcarbaphenem(I) antibiotics, is manufactured. In formula, R is active residual group having an...

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Hauptverfasser: KIM, KYUNG-SOO, HWANG, TAE-SUB, JUNG, HEE-JUNG, LEE, MI-JUNG, AHN, KOO-HYUN, KIM, HONG-KI, KIM, WAN-JOO
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Sprache:eng
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Zusammenfassung:(3S,4S)-3{(1R)-1-[(t-Butyldimethylsillyl)oxy ethyl}-4-{[(1R)-1-methyl-(4,4-dialkyl-2-thioxo-1,3-oxaorthiazolidine)-3)-yl methyl}azethidine-2-one(II), useful as an intermediate in manufacturing 1-beta-methylcarbaphenem(I) antibiotics, is manufactured. In formula, R is active residual group having an anti biosis, R1 is t-butyldimethylsillyl group of hydroxy protecting group, R2 is H or low alkyl group, X1,X2 are O or S.