PROCESS FOR PREPARING OF ÑÔ-METHYLAZETIDINONE DERIVATIVE
(3S,4S)-3{(1R)-1-[(t-Butyldimethylsillyl)oxy ethyl}-4-{[(1R)-1-methyl-(4,4-dialkyl-2-thioxo-1,3-oxaorthiazolidine)-3)-yl methyl}azethidine-2-one(II), useful as an intermediate in manufacturing 1-beta-methylcarbaphenem(I) antibiotics, is manufactured. In formula, R is active residual group having an...
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Format: | Patent |
Sprache: | eng |
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Zusammenfassung: | (3S,4S)-3{(1R)-1-[(t-Butyldimethylsillyl)oxy ethyl}-4-{[(1R)-1-methyl-(4,4-dialkyl-2-thioxo-1,3-oxaorthiazolidine)-3)-yl methyl}azethidine-2-one(II), useful as an intermediate in manufacturing 1-beta-methylcarbaphenem(I) antibiotics, is manufactured. In formula, R is active residual group having an anti biosis, R1 is t-butyldimethylsillyl group of hydroxy protecting group, R2 is H or low alkyl group, X1,X2 are O or S. |
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