GONADOLIBERIN ANALOGUE AND ITS PRODUCTION

GONADOLIBERIN ANALOGUE AND ITS PRODUCTION

The invention relates to peptides of the formula in which X is absent or is hydrogen or acyl; A is Pgl, de-hydro-Pro, Pro, D-Thi or D-Pgl or represents optionally substituted D-Nal(2), D-Phe or D-Trp; B is His or optionally substituted D-Phe; C is Trp, D-Thi, D-Pal(3) or optionally substituted D-Trp...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: TSUENETSUKU KOORARU, BUORUFUGANGU KEENIHI, YURUGEN KURUTO ZANDOU
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to peptides of the formula in which X is absent or is hydrogen or acyl; A is Pgl, de-hydro-Pro, Pro, D-Thi or D-Pgl or represents optionally substituted D-Nal(2), D-Phe or D-Trp; B is His or optionally substituted D-Phe; C is Trp, D-Thi, D-Pal(3) or optionally substituted D-Trp; D is Tyr, Arg of His; E is D-Ser(R1), beta -Asn, beta -Asp-OMe, D-Thi or -NH-CH(CH2R2)-CO-; F is Ser(R1), Leu, Trp or Phe; G is Gly-NH2, Aza-Gly-NH2, D-Ala-NH2 or NH-alkyl; R1 is glycosyl and R2 is hydrogen, acyl, aryl or heteroaryl. The invention also relates to methods for the preparation of these peptides, agents containing them and their use.