ISOQUINOLINE DERIVATIVE

NEW MATERIAL:A compound expressed by formula I (R1 is 1-4C lower alkyl or cyclopropyl; R2 is formyl, 1-4C lower alkanoyl, benzoyl, 1-4C lower alkyl, 1-4C lower alkenyl, 1-4C hydroxy-substituted lower alkyl or 1-4C perfluoroalkyl; R3 is 4-pyridyl or 2-pyridyl). EXAMPLE:4-Ethyl-1-methyl-7-(4-pyridyl)-...

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Hauptverfasser:	KAJITANI SEITARO, MARUYAMA MASAHIKO, OOTSUKA KENGO, KAIHO TATSUO, HIRAYAMA MAKOTO
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	KAJITANI SEITARO MARUYAMA MASAHIKO OOTSUKA KENGO KAIHO TATSUO HIRAYAMA MAKOTO
description	NEW MATERIAL:A compound expressed by formula I (R1 is 1-4C lower alkyl or cyclopropyl; R2 is formyl, 1-4C lower alkanoyl, benzoyl, 1-4C lower alkyl, 1-4C lower alkenyl, 1-4C hydroxy-substituted lower alkyl or 1-4C perfluoroalkyl; R3 is 4-pyridyl or 2-pyridyl). EXAMPLE:4-Ethyl-1-methyl-7-(4-pyridyl)-5,6,7,8-tetrahydro-3(2H)i-soqui noline. USE:A cardiotonic agent. PREPARATION:For example, a 2-acyl-4-(4-pyridyl)cyclohexanone expressed by formula II is reacted with an alkanolyacetamide in the presence of piperidinediethylamine, etc., and the resultant reaction product is subjected to the wolff-kishner reduction to provide the compound expressed by formula I.
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EXAMPLE:4-Ethyl-1-methyl-7-(4-pyridyl)-5,6,7,8-tetrahydro-3(2H)i-soqui noline. USE:A cardiotonic agent. PREPARATION:For example, a 2-acyl-4-(4-pyridyl)cyclohexanone expressed by formula II is reacted with an alkanolyacetamide in the presence of piperidinediethylamine, etc., and the resultant reaction product is subjected to the wolff-kishner reduction to provide the compound expressed by formula I.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1988</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19880312&DB=EPODOC&CC=JP&NR=S6357585A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19880312&DB=EPODOC&CC=JP&NR=S6357585A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KAJITANI SEITARO</creatorcontrib><creatorcontrib>MARUYAMA MASAHIKO</creatorcontrib><creatorcontrib>OOTSUKA KENGO</creatorcontrib><creatorcontrib>KAIHO TATSUO</creatorcontrib><creatorcontrib>HIRAYAMA MAKOTO</creatorcontrib><title>ISOQUINOLINE DERIVATIVE</title><description>NEW MATERIAL:A compound expressed by formula I (R1 is 1-4C lower alkyl or cyclopropyl; R2 is formyl, 1-4C lower alkanoyl, benzoyl, 1-4C lower alkyl, 1-4C lower alkenyl, 1-4C hydroxy-substituted lower alkyl or 1-4C perfluoroalkyl; R3 is 4-pyridyl or 2-pyridyl). EXAMPLE:4-Ethyl-1-methyl-7-(4-pyridyl)-5,6,7,8-tetrahydro-3(2H)i-soqui noline. USE:A cardiotonic agent. PREPARATION:For example, a 2-acyl-4-(4-pyridyl)cyclohexanone expressed by formula II is reacted with an alkanolyacetamide in the presence of piperidinediethylamine, etc., and the resultant reaction product is subjected to the wolff-kishner reduction to provide the compound expressed by formula I.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1988</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBD3DPYPDPX08_fx9HNVcHEN8gxzDPEMc-VhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfFeAcFmxqbmphamjsZEKAEAvxQftA</recordid><startdate>19880312</startdate><enddate>19880312</enddate><creator>KAJITANI SEITARO</creator><creator>MARUYAMA MASAHIKO</creator><creator>OOTSUKA KENGO</creator><creator>KAIHO TATSUO</creator><creator>HIRAYAMA MAKOTO</creator><scope>EVB</scope></search><sort><creationdate>19880312</creationdate><title>ISOQUINOLINE DERIVATIVE</title><author>KAJITANI SEITARO ; MARUYAMA MASAHIKO ; OOTSUKA KENGO ; KAIHO TATSUO ; HIRAYAMA MAKOTO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPS6357585A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1988</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>KAJITANI SEITARO</creatorcontrib><creatorcontrib>MARUYAMA MASAHIKO</creatorcontrib><creatorcontrib>OOTSUKA KENGO</creatorcontrib><creatorcontrib>KAIHO TATSUO</creatorcontrib><creatorcontrib>HIRAYAMA MAKOTO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KAJITANI SEITARO</au><au>MARUYAMA MASAHIKO</au><au>OOTSUKA KENGO</au><au>KAIHO TATSUO</au><au>HIRAYAMA MAKOTO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ISOQUINOLINE DERIVATIVE</title><date>1988-03-12</date><risdate>1988</risdate><abstract>NEW MATERIAL:A compound expressed by formula I (R1 is 1-4C lower alkyl or cyclopropyl; R2 is formyl, 1-4C lower alkanoyl, benzoyl, 1-4C lower alkyl, 1-4C lower alkenyl, 1-4C hydroxy-substituted lower alkyl or 1-4C perfluoroalkyl; R3 is 4-pyridyl or 2-pyridyl). EXAMPLE:4-Ethyl-1-methyl-7-(4-pyridyl)-5,6,7,8-tetrahydro-3(2H)i-soqui noline. USE:A cardiotonic agent. PREPARATION:For example, a 2-acyl-4-(4-pyridyl)cyclohexanone expressed by formula II is reacted with an alkanolyacetamide in the presence of piperidinediethylamine, etc., and the resultant reaction product is subjected to the wolff-kishner reduction to provide the compound expressed by formula I.</abstract><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	ISOQUINOLINE DERIVATIVE
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