ANGIOTENSINASE-INHIBITING AGENT

PURPOSE:To provide the titled inhibiting agent containing a tripeptide as an active component. CONSTITUTION:The tripeptide of formula is separated and purified by subjecting swine plasma to gel-filtration, etc., with various kineds of filler (e.g., column chromatography filled with Amberlite(R)) referring angiotensinase-inhibiting activity as an index. The tripeptide is used as active component of the objective angiotensinase-inhibiting agent. The tripeptide of formula is combined with a drug-preparation carrier, a diluent or other additive to obtain a solution or an injection such as freeze-dried powder which is to be dissolved before use. It is parenteraly administered e.g. by intravenous injection. The inhibiting agent is suitable for mammals including human being producing angiotensinase in the body. Dose: 0.001-10mg/kg and 1-4 doses pser day. EFFECT:Useful as a preventive and remedy for hypertension or diagnostic agent for the disease.