RING-REDUCED MACROLIDE ANTIBIOTIC

Novel 12-membered lactone and 11-membered lactone derivatives of erythromycin, having antimicrobial activity against certain Gram-positive pathogens such as Streptococcus pyogenes and Gram-negative cocci such as Haemophilus influenzae, and useful as intermediates to other macrolide derivatives, are...

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Hauptverfasser:	HAABAATO ANDORIYUU KAASUTO, JIYURII AN UINDO
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	Novel 12-membered lactone and 11-membered lactone derivatives of erythromycin, having antimicrobial activity against certain Gram-positive pathogens such as Streptococcus pyogenes and Gram-negative cocci such as Haemophilus influenzae, and useful as intermediates to other macrolide derivatives, are disclosed. They have the formula (A) R is hydrogen or C1-C5-alkanoyl; R is -N(CH3)2 or -N(CH3)2->O; and either a) R and R taken together form a bond, and R and R are 1) either both hydroxyl or 2) taken together form a bond; or b) each of R and R taken together and R and R taken together form a keto group; provided that, when R is an (a) group and R is -N(CH3)2, both R and R together and R and R together cannot form a bond; or a salt thereof. b