WATER-INSOLUBLE PARTICLE, IMMUNOLOGICAL REACTIVE REAGENT, ANALYSIS ELEMENT AND USAGE THEREOF

A water-insoluble polymeric particle has an inner core comprising a detectable tracer material distributed in a first polymer for which the tracer material has a high affinity. This first polymer has a glass transition temperature (Tg1) less than 100 DEG C. The particle also has an outer shell compr...

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Bibliographische Detailangaben
Hauptverfasser:	SUUZAN JIIN DANIERUSON, BURAIAN ANSONII SUNAIDAA, ROBAATO TOROKONISU BERII, RICHIYAADO KARUBIN SATSUTON, SUUZAN BURENAN RITORUHEIRU
Format:	Patent
Sprache:	eng
Schlagworte:	AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G CHEMISTRY COMPOSITIONS BASED THEREON GENERAL PROCESSES OF COMPOUNDING INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS MEASURING METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PHYSICS TESTING THEIR PREPARATION OR CHEMICAL WORKING-UP WORKING-UP
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Beschreibung
Zusammenfassung:	A water-insoluble polymeric particle has an inner core comprising a detectable tracer material distributed in a first polymer for which the tracer material has a high affinity. This first polymer has a glass transition temperature (Tg1) less than 100 DEG C. The particle also has an outer shell comprising a second polymer for which the tracer material has substantially less affinity relative to said first polymer. This second polymer has a glass transition temperature (Tg2) which is greater than or equal to the term [Tg1-10 DEG C]. It also contains groups which are either reactive with free amino or sulfhydryl groups of an immunoreactive species or which can be activated for reaction with such groups. Such a species can be covalently attached to this particle to form an immunoreactive reagent which is useful in analytical elements and various analytical methods including immunological methods, for example, agglutination assays.