COMPOSITION FOR TREATING ALVEOLAR BONE METABOLISM

PURPOSE:To obtain the titled composition remaining at an administration site for a long time and continuously showing controlling action on bone metabolism, by blending a base comprising hydrogel, a methacrylic acid copolymer and a solubilizer with a remedy for bone betabolism. CONSTITUTION:(A) Hydrogel comprising A1: a water-soluble high polymer substance (e.g. PVA or carrageenan, especially hydroxyethyl cellulose) and A2: a polyhydric alcohol (e.g. glycerin or propylene glycol) is blended with (B) an aminoalkyl methacrylate copolymer E, an aminoalkyl methacrylate copolymer RS or a mixture thereof, (C) a solubilizer (e.g. triacetin) to dissolve the components B but not to have compatibility with the polyhydric alcohol and (D) a remedy for bone metabolism or a salt thereof in the weight ratio of the component B:C of 1:2-1:25. The amount of the component A1 blended in the component A is 0.2-10wt.% based on sum of the composition and the weight ratio of the component A1:A is preferably 1:9-1:400, with a remedy for bone betabolism.