PEPTIDE COMPOUND, ITS PRODUCTION AND PHARMACEUTICAL COMPOSITION CONTAINING SAID COMPOUND

NEW MATERIAL:The compound of formula I [R is (substituted)aryl, lower alkyl or lower cycloalkyl; R is H or lower alkyl; R and R may together with adjacent N form a (substituted)heterocyclic group] and its salt. EXAMPLE:2(S)-( N-morpholinocarbonyl-L-phenylalanyl N-methyl-L-histidyl )ami no-L-cyclohexyl-3-(S)-hydroxy-6-methylheptane. USE:A resin inhibitor and hypotensor. It can be administered by oral administra tion. PREPARATION:A compound of formula II (R is N-protecting group; R is H or N-protecting group; R is H or lower alkyl), its reactive derivative at carboxyl group or their salt is made to react with a compound of formula III (R is lower alkyl), its reactive derivative at amino group or their salt.