ANTHRACYCLINE COMPOUND AND USE THEREOF

NEW MATERIAL:A compound expressed by formulas I or II [R and R are H or OH; R is H or formula III; R is formulas IV-VIII, etc., (R is H, alkyl, fluoroalkyl, etc.; R and R are H, alkyl, OH, etc.; R is OH, carboxyl, amino, etc.; R is OH, carboxyl, amino, etc.) when R is H and R is amino or formula IX...

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Bibliographische Detailangaben
Hauptverfasser:	KAWAI HIROYUKI, TAKEUCHI TOMIO, NAKAJIMA SHIYOUHACHI
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	NEW MATERIAL:A compound expressed by formulas I or II [R and R are H or OH; R is H or formula III; R is formulas IV-VIII, etc., (R is H, alkyl, fluoroalkyl, etc.; R and R are H, alkyl, OH, etc.; R is OH, carboxyl, amino, etc.; R is OH, carboxyl, amino, etc.) when R is H and R is amino or formula IX when R is formula III; R is H or OH; R is amino or formula IX]. EXAMPLE:N-Trifluoroacetyl-13-deoxocarminomycine. USE:An antiulcer agent. PREPARATION:For example, a 13-deoxocarminomycine (R20X) is reacted with an acid chloride or acid anhydride in a basic solvent such as pyridine to provide the compound expressed by formula I (R is H; R is formula IV) or a compound expressed by formula X is treated with an oxidant such as Jones reagent in a solvent such as acetone to provide the compound expressed by formula II.