MANUFACTURE OF ACYLATED HETEROCYCLIC COMPOUND

MANUFACTURE OF ACYLATED HETEROCYCLIC COMPOUND

The invention relates to a process for the preparation of 1-[3'-{bromo}-(2'S)-{methyl}-propionyl]-pyrrolidine-(2S)-carboxylic acid of the formula < IMAGE > or its monohydrate, if desired with subsequent recrystallisation of the product from water, in which the 3'-[bromo]-(2'...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: YAANOSU FUISUSHIYAA, AIBUA PETAINIYUI, RAASUROO DOBAI, MIHAARII MAYORU, RAASUROO KONKUZU, YAANOSU TAAMUPE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention relates to a process for the preparation of 1-[3'-{bromo}-(2'S)-{methyl}-propionyl]-pyrrolidine-(2S)-carboxylic acid of the formula < IMAGE > or its monohydrate, if desired with subsequent recrystallisation of the product from water, in which the 3'-[bromo]-(2'S)-[methyl]-propionic acid [pyrrolidine-(2S)-carboxylic acid benzyl ester] salt of the formula < IMAGE > is reacted with a condensing agent in one or more inert organic solvent(s) and the benzyl 1-[3'-[bromo]-(2'S)-[methyl]-propionyl] pyrrolidine-(2S)-carboxylate of the formula < IMAGE > is debenzylated by catalytic hydrogenation.r