HEPATIC CELL GROWTH FACTOR
NEW MATERIAL:A hepatic cell growth factor [estimated molecular weight by SDS-PAGE (under non-reducing condition), 76,000-92,000; active to enable growth of hepatic cell; losing the above activity by the heat-treatment at 80 deg.C for 10min; losing the above activity by trypsin digestion and chymotry...
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| creator | TSUBOUCHI HIROHITO NAKAYAMA HIROYUKI TAKAHASHI KOZO DAIKUHARA YASUSHI AIDA EIICHI HASHIMOTO SHUJI HIRONO SHIYUUICHI |
| description | NEW MATERIAL:A hepatic cell growth factor [estimated molecular weight by SDS-PAGE (under non-reducing condition), 76,000-92,000; active to enable growth of hepatic cell; losing the above activity by the heat-treatment at 80 deg.C for 10min; losing the above activity by trypsin digestion and chymotrypsin digestion; having strong affinity to heparin]. USE:Remedy for hepatic diseases such as acute hepatitis, chronic hepatitis, hepatocirrhosis, etc., and post-operative remedy for hepatectomy. Antigen for establishing immunological diagnosis of various diseases. PREPARATION:Human blood, especially blood (plasma) of patient of fulminant hepatitis is heated at 56 deg.C for about 15min, fractionated with ammonium sulfate and a fraction precipitated at an ammonium sulfate concentration of about 1.1-2.1M is collected to obtain the active component. The obtained component can be purified by gel-filtration using a carrier, ion exchange chromatography using an anion exchange material such as DEAE, etc. |
| format | Patent |
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USE:Remedy for hepatic diseases such as acute hepatitis, chronic hepatitis, hepatocirrhosis, etc., and post-operative remedy for hepatectomy. Antigen for establishing immunological diagnosis of various diseases. PREPARATION:Human blood, especially blood (plasma) of patient of fulminant hepatitis is heated at 56 deg.C for about 15min, fractionated with ammonium sulfate and a fraction precipitated at an ammonium sulfate concentration of about 1.1-2.1M is collected to obtain the active component. The obtained component can be purified by gel-filtration using a carrier, ion exchange chromatography using an anion exchange material such as DEAE, etc.</description><language>eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1988</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19880130&DB=EPODOC&CC=JP&NR=S6322526A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25551,76302</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19880130&DB=EPODOC&CC=JP&NR=S6322526A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TSUBOUCHI HIROHITO</creatorcontrib><creatorcontrib>NAKAYAMA HIROYUKI</creatorcontrib><creatorcontrib>TAKAHASHI KOZO</creatorcontrib><creatorcontrib>DAIKUHARA YASUSHI</creatorcontrib><creatorcontrib>AIDA EIICHI</creatorcontrib><creatorcontrib>HASHIMOTO SHUJI</creatorcontrib><creatorcontrib>HIRONO SHIYUUICHI</creatorcontrib><title>HEPATIC CELL GROWTH FACTOR</title><description>NEW MATERIAL:A hepatic cell growth factor [estimated molecular weight by SDS-PAGE (under non-reducing condition), 76,000-92,000; active to enable growth of hepatic cell; losing the above activity by the heat-treatment at 80 deg.C for 10min; losing the above activity by trypsin digestion and chymotrypsin digestion; having strong affinity to heparin]. 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USE:Remedy for hepatic diseases such as acute hepatitis, chronic hepatitis, hepatocirrhosis, etc., and post-operative remedy for hepatectomy. Antigen for establishing immunological diagnosis of various diseases. PREPARATION:Human blood, especially blood (plasma) of patient of fulminant hepatitis is heated at 56 deg.C for about 15min, fractionated with ammonium sulfate and a fraction precipitated at an ammonium sulfate concentration of about 1.1-2.1M is collected to obtain the active component. The obtained component can be purified by gel-filtration using a carrier, ion exchange chromatography using an anion exchange material such as DEAE, etc.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | HEPATIC CELL GROWTH FACTOR |
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