NOVEL SUBSTANCE NEPLANOCIN F AND PRODUCTION THEREOF

NEW MATERIAL:Neplanocin F expressed by formula I. USE:The above-mentioned compound has pharmacological effect and is useful as an antithrombotic agent and further an intermediate for purine compound having pharmacological action. PREPARATION:Ampullariella.espi A11079 (FERM P-4494) which is neplanoci...

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Hauptverfasser:	FUJII TADAYO, TSUJINO MASATOSHI, YAGINUMA SATOSHI, MUTO NAOKI, KOTANI MASARU
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	NEW MATERIAL:Neplanocin F expressed by formula I. USE:The above-mentioned compound has pharmacological effect and is useful as an antithrombotic agent and further an intermediate for purine compound having pharmacological action. PREPARATION:Ampullariella.espi A11079 (FERM P-4494) which is neplanocin F-producing fungus is cultivated im a culture medium and the aimed compound is obtained from the cultivated product. The above-mentioned neplanocin F- producing actinomyces is separated from a soil of leek field in Myokoukougen- Chou Nakakubishiro-Gun Niigata prefecture. Neplanocin F has the following pysicochemical properties: Weakly basic and white needle crystal; melting point, 223 deg.C (decomposed); optical rotation [alpha]D =-6.6 (C=0.8%, H2O); solubility, soluble in water, dimethylsulfoxide and acetic acid and insoluble in ethyl acetate, chloroform, benzene, etc.; color reaction, positive to potassium permanganate decolor reaction and negative to ferric chloride reaction, ninhydrin reaction and Fehling's reaction.