NOVEL PREDNISOLONE ESTER DERIVATIVE

NOVEL PREDNISOLONE ESTER DERIVATIVE

NEW MATERIAL:A compound expressed by formula I (R is formula II-IV). EXAMPLE:(11beta,17-Dihydroxy-3,20-dioxo-1,4-pregnadien-21-yl) 1-(4-chlorobenzoyl)-5- methoxy-2-methylindole-3-acetate. USE:An anti-inflammatory agent having powerful anti-inflammatory and diuretic action as well as low toxcity and...

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Bibliographische Detailangaben
Hauptverfasser: KATORI TATSUHIKO, KOMOTO TERUO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Beschreibung
Zusammenfassung:NEW MATERIAL:A compound expressed by formula I (R is formula II-IV). EXAMPLE:(11beta,17-Dihydroxy-3,20-dioxo-1,4-pregnadien-21-yl) 1-(4-chlorobenzoyl)-5- methoxy-2-methylindole-3-acetate. USE:An anti-inflammatory agent having powerful anti-inflammatory and diuretic action as well as low toxcity and useful for treating chronic rheumatic diseases, etc., accompanied by edema. PREPARATION:For example, prednisolone expressed by formula V is reacted with an acid chloride expressed by the formula RCOC in equimolar amounts. The above-mentioned reaction is normally carried out in the presence of a base (e.g. triethylamine, etc.) in a solvent, such as THF, etc., at room temperature for 1-24hr.