NOVEL PYRROLOBENZIMIDAZOLE, ITS PRODUCTION AND CARDIAC- AND CIRCULATORY SYSTEM DISEASE DRUG CONTAINING THE SAME

Pyrrolobenzimidazoles of the formula: are useful for treatment of heart and circulatory diseases. R1 is substituted phenyl; or optionally substituted naphthyl or a five- or six-membered heterocyclic group which can be condensed with a phenyl ring to form a bicyclic radical. R2 is hydrogen, alkyl, al...

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Hauptverfasser: KURAUSU SHIYUTORAIN, BUARUTAA GUNAARU FURIIBE, ARUFUREETO MERUTENSU, ERUBUIN BEEMU
Format: Patent
Sprache:eng
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Zusammenfassung:Pyrrolobenzimidazoles of the formula: are useful for treatment of heart and circulatory diseases. R1 is substituted phenyl; or optionally substituted naphthyl or a five- or six-membered heterocyclic group which can be condensed with a phenyl ring to form a bicyclic radical. R2 is hydrogen, alkyl, alkenyl or cycloalkenyl; R3 is alkyl, alkenyl or hydroxyalkyl or with R2 together forms cycloakylene; or R2 and R3 together form alkylidene or cycloalkylidene. R4 is hydrogen or lower alkanoyl. X is a valency bond, alkylene, vinylene, imino or carbonylamino. T stands for two hydrogen atoms. When X is a valency bond, R1 can also be hydrogen, hydrocarbyl which may also contain oxygen, amino, sulfur, carbonyl and sulfonyl groups. When X is imino or carbonylamino or when R1 is a bicyclic radical, T can also be oxygen. The compounds also include the tautomers and physiologically acceptable salts with inorganic and organic acids.