HYPOLIPEMIC AGENT CONTAINING 7-FLUOROPROSTACYCLINES AS ACTIVE COMPONENT

PURPOSE:To provide a hypolipemic agent containing a 7-fluoroprostacycline compound as an active component and exhibiting extremely strong effect to lower the level of lipid such as cholesterol, triglyceride, etc., in blood. CONSTITUTION:The objective agent can be produced by mixing a 7- fluoroprosta...

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Bibliographische Detailangaben
Hauptverfasser: OTA TOMOHIRO, SAKAUCHI KIYOSHI, KUROZUMI SEIJI
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:PURPOSE:To provide a hypolipemic agent containing a 7-fluoroprostacycline compound as an active component and exhibiting extremely strong effect to lower the level of lipid such as cholesterol, triglyceride, etc., in blood. CONSTITUTION:The objective agent can be produced by mixing a 7- fluoroprostacycline compound of formula (R is H, 1-10C alkyl or 1 equivalent of cation; R is 1-10C alkyl or 3-8C cycloalkyl) with a carrier and forming the mixture to a drug by conventional method. It can be administered orally or parenterally e.g. by rectal infusion, subcutaneous injection, intramuscular injection, intravenous injection, transcutaneous application, etc., and preferably oral administration or intravenous injection. Dose of the active components is 1mug-100mg daily for adult in the case of using as a remedy for hepatopathy. The compound of formula is e.g. (7R)-16,17,18,19,20-pentanor-15-cyclopentyl-7- fluoroprostaglandin I2 sodium salt.