NOVEL SUBSTITUTED DIHYDROPYRIDINE DERIVATIVE, ITS PRODUCTION, DRUG COMPOSED OF SAID DERIVATIVE AND ITS PRODUCTION

NOVEL SUBSTITUTED DIHYDROPYRIDINE DERIVATIVE, ITS PRODUCTION, DRUG COMPOSED OF SAID DERIVATIVE AND ITS PRODUCTION

The invention relates to new substituted dihydropyridine derivatives of the general formula (I), wherein R1 and R6 are as defined herein after, the racemic and optically active variants as well as mixtures thereof, furthermore the acid addition salts of these compounds, pharmaceutical compositions c...

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Hauptverfasser: JIYOENJII NAJII NEEE CHIYOKAASHIYU, ZUZA RAANGU NEEE RIIMERU, IRONA BOODEI, EEBUA BOZOO, JIYORUJII CHIEE, JIYORUJI RABUROTSUKII, JIYURA HORUBUAATO, RAASUROO TSUORUNERU, ISHIYUTOBUAAN EREKESHIYU, GEEZA SHIRAAJII, ANDORAASHIYU BUARUROO, RAASUROO YASURITSU, YOOJIEFU BORUSHI
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to new substituted dihydropyridine derivatives of the general formula (I), wherein R1 and R6 are as defined herein after, the racemic and optically active variants as well as mixtures thereof, furthermore the acid addition salts of these compounds, pharmaceutical compositions containing the same and a process for the preparation thereof. The compounds of the general formula (I) can be advantageously applied for the treatment of pathologically severe hypertensions, their toxicity is low and they possess an advantageous therapeutic index.