NOVEL DECAHYDROQUINOLINE DERIVATIVE, ITS PRODUCTION, NEW INTERMEDIATE OBTAINED, ITS USE AS DRUG AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

A compound selected from the group consisting of all enantiomeric and diastereoisomeric forms of a decahydroquinoline of the formula I wherein R1 is alkyl of 1 to 5 carbon atoms, R2 is selected from the group consisting of hydrogen and akyl of 1 to 5 carbon atoms, A is selected from the group consis...

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Hauptverfasser: FURANSOWA KUREMANSU, MISHIERU FUORUTAN, FURANSOWAAZU DOREBARE, ODEIRU RU MARUTORE
Format: Patent
Sprache:eng
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Zusammenfassung:A compound selected from the group consisting of all enantiomeric and diastereoisomeric forms of a decahydroquinoline of the formula I wherein R1 is alkyl of 1 to 5 carbon atoms, R2 is selected from the group consisting of hydrogen and akyl of 1 to 5 carbon atoms, A is selected from the group consisting of -(CH2)n-, -CH2O- and alkylene substituted with alkyl having a total of 2 to 8 carbon atoms, n is an integer from 0 to 5, Z is selected from the group consisting of optionally substituted phenyl, optionally substituted naphthyl, optionally substituted indenyl, optionally substituted heteromonocycle of 5 to 6 members and optionally substituted heterobicycle with the proviso that when Z is o-alkoxy-phenyl, A is not -(CH2)n- in which n is O, and their non-toxic, pharmaceutically acceptable acid addition salts and their quaternary ammonium salts and intermediates having analgesic, diuretic, hypotensive, anti-arrithmic and anti-cerebral-ischaemic properties.