PRODUCTION OF TRIAZOLE DERIVATIVE

PURPOSE:To advantageously obtain the titled compound useful as a beta-lactamase inhibitor or an intermediate thereof under a low reaction pressure, by reacting an azide derivative with acetylene under specific condition. CONSTITUTION:An azide derivative expressed by formula I (R represents H or carb...

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Bibliographische Detailangaben
Hauptverfasser:	SUZUKI KOHEI, OSAI YOSHIO, AOKI KYOJI
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Beschreibung
Zusammenfassung:	PURPOSE:To advantageously obtain the titled compound useful as a beta-lactamase inhibitor or an intermediate thereof under a low reaction pressure, by reacting an azide derivative with acetylene under specific condition. CONSTITUTION:An azide derivative expressed by formula I (R represents H or carboxyl-protecting group) (example; 2beta-azidomethyl-2alpha-methylpenam-3alpha- carboxylic acid 1,1-dioxide p-nitrobenzyl ester, etc.) is reacted with acetylene in the presence of a solvent having >=50 deg.C boiling point under normal pressure and a high solubility of acetylene (example; acetone, THF, etc.) under a pressure of