ANTIBIOTIC SUBSTANCE F-0769 AND PRODUCTION THEREOF

NEW MATERIAL:The antibiotic substance having the following physical and chemical properties. Appearance, white or pale yellow powder; melting point, 245-250 deg.C; specific rotation, [alpha] D=-37.5 deg. (c=1, methanol); solubility, soluble in methanol, ethanol, acetone, chloroform, ethyl acetate an...

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Hauptverfasser: SUGIYAMA MACHIKO, KIYONO AKIO, SUGAWARA HIDEO, SUZUKI SHOJI, TAKASHINA TOMONORI, TAKAHASHI NOBUKO, SUZUKI HIROSHI, MIYAZAKI YUKIO, IWAGAYA YASUO
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Sprache:eng
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Zusammenfassung:NEW MATERIAL:The antibiotic substance having the following physical and chemical properties. Appearance, white or pale yellow powder; melting point, 245-250 deg.C; specific rotation, [alpha] D=-37.5 deg. (c=1, methanol); solubility, soluble in methanol, ethanol, acetone, chloroform, ethyl acetate and benzene and insoluble in water and hexane; elemental analysis (%), C 57.53, H 7.36, O 21.17, N 12.97; amino acid analysis, positive to threonine, valine and leucine; color reaction, positive to iodine reaction and potassium permanganate reaction, negative to ninhydrin reaction and ferric chloride reaction. USE:Antibacterial agent. PREPARATION:Streptomyces violaceusniger F-0769 (FERM P-1264) belonging to Streptomyces genus is cultured and the produced antibiotic substance F-0769 is separated from the cultured product.