MANUFACTURE OF 3-CHLORO-5-ISOAZOLEACETIC ACID

MANUFACTURE OF 3-CHLORO-5-ISOAZOLEACETIC ACID

3-Chloro-5-isoxazoleacetic acid is prepared from 3-chloro-5-isoxazolepropionic acid by conversion of the latter to E-3-chloro-5-isoxazoleacrylic acid. This is first converted to the acid chloride, then to the acid azide, which is subjected to a Curtius degradation and hydrolysed and the hydrolysed p...

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Hauptverfasser: JIYURA HORUNIYAAKU, JIYURA SHIMIGU, IRUDEIKOO MIHOOKU, YOOJIEFU FUETSUTAA, YOOJIEFU NAJIE, GAABORU DORESUCHIYARU, KAAROI RENPERUTO, KAARORIYU ZAUERU, SAANDORU EREKU, YOOJIEFU NIYUITORAI, JIYUJIYANNA GOMUBOSHIYU, MIKUROOSU MIHOOKU
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:3-Chloro-5-isoxazoleacetic acid is prepared from 3-chloro-5-isoxazolepropionic acid by conversion of the latter to E-3-chloro-5-isoxazoleacrylic acid. This is first converted to the acid chloride, then to the acid azide, which is subjected to a Curtius degradation and hydrolysed and the hydrolysed product is condensed with hydroxylamine to give the corresponding nitrile, which is hydrolysed to give said 3-chloro-5-isoxazoleacetic acid.