CYCLOPHENTENONYL EPOXYHEPTANOIC ACID DERIVATIVE

CYCLOPHENTENONYL EPOXYHEPTANOIC ACID DERIVATIVE

NEW MATERIAL:The compound of formula I (n is 1 or 0 to form epoxide or double bond; R and R are H or lower alkyl; R is alkyl, cycloalkyl or aryl or R and R together form polymethylene). EXAMPLE:7-( 1-Oxa-2,2-pentamethylene-5-oxo-6-spiro[4.2]hepten-4-yl )-5,6-oxohe ptanoic acid methyl ester. USE:A dr...

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Bibliographische Detailangaben
Hauptverfasser: SAKAI KUNIKAZU, YAMASHITA MITSUO, YAMADA KAORU, TOIDA NOBUKO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:NEW MATERIAL:The compound of formula I (n is 1 or 0 to form epoxide or double bond; R and R are H or lower alkyl; R is alkyl, cycloalkyl or aryl or R and R together form polymethylene). EXAMPLE:7-( 1-Oxa-2,2-pentamethylene-5-oxo-6-spiro[4.2]hepten-4-yl )-5,6-oxohe ptanoic acid methyl ester. USE:A drug. An antitumor agent. It is a substance corresponding to epoxidized 12-dehydroprostaglandin A-mimic compound and has strong antitumor activity. PREPARATION:The compound of formula I wherein n is 0 can be produced by epoxidizing the double bond of 7-(2-alkylidene-5-oxo-3-cyclopentenyl)-5- heptenoic acid derivative of formula II with an oxidizing agent such as m- chloroperbenzoic acid at room temperature. The product can be converted to another compound of formula I wherein n is 1 by further epoxidization.