PRODUCTION OF N-(1(S)-ETHOXYCARBONYL-3-PHENYLPROPYL)-L-ALANYL-L-PROLINE

PRODUCTION OF N-(1(S)-ETHOXYCARBONYL-3-PHENYLPROPYL)-L-ALANYL-L-PROLINE

PURPOSE:To industrially and advantageously obtain the titled compound useful as an antihypertensive agent, by reacting N-carboxy anhydride of N-[1(S)- ethoxycarbonyl-3-L-phenylpropyl]-L-alanine with L-proline in the presence of a base. CONSTITUTION:N-Carboxy anhydride of N-[1(S)-ethoxycarbonyl-3-phe...

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Bibliographische Detailangaben
Hauptverfasser: INOUE KENJI, WATANABE KIYOSHI, YANAGIDA YOSHIBUMI, OHASHI TAKEHISA, TAKAHASHI SATOMI
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:PURPOSE:To industrially and advantageously obtain the titled compound useful as an antihypertensive agent, by reacting N-carboxy anhydride of N-[1(S)- ethoxycarbonyl-3-L-phenylpropyl]-L-alanine with L-proline in the presence of a base. CONSTITUTION:N-Carboxy anhydride of N-[1(S)-ethoxycarbonyl-3-phenylpropyl]- L-alanine is reacted with L-proline in the presence of a base, preferably hydroxide, carbonate or bicarbonate of an alkali metal, secondary amine, tertiary amine or quaternary ammonium hydroxide, preferably in a mixed solvent of an organic solvent, e.g. acetone, dioxane, THF or acetonitrile, and water while keeping the pH at constant value 9-10 to afford the aimed compound.