FLURBIPROFEN PREPARATION FOR OPHTHALMIC ADMINISTRATION

FLURBIPROFEN PREPARATION FOR OPHTHALMIC ADMINISTRATION

PURPOSE:To obtain a preparation for ophthalmic administration, having high transferability to protomerite and useful for the remedy of inflammation of conjunctiva and ectocornea in ophthalmic field, by adding flurbiprofen (FP) to fat emulsion. CONSTITUTION:Soybean oil is mixed with phospholipid and...

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Bibliographische Detailangaben
Hauptverfasser: OKAMOTO HIROYUKI, OKUMURA MAKOTO, KONISHI YOSHIAKI, ICHIKAWA KIYONOSHIN, SUYAMA TADAKAZU, MIZUSHIMA YUTAKA, YOKOYAMA KAZUMASA, SUGIO NARUTOSHI, TONO MASAO, UCHIDA KATSUHIRO
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:PURPOSE:To obtain a preparation for ophthalmic administration, having high transferability to protomerite and useful for the remedy of inflammation of conjunctiva and ectocornea in ophthalmic field, by adding flurbiprofen (FP) to fat emulsion. CONSTITUTION:Soybean oil is mixed with phospholipid and FP [2-(2-fluoro-4- biphenylyl)propionic acid] or its derivative and, if necessary, with an additive such as emulsifying assistant, stabilizer, etc., at prescribed ratios. The mixture is heated to obtain a solution, homogenized to a W/O-type dispersion with a homogenizer, added with a prescribed amount of water and homogenized again to convert the dispersion to an O/W-type emulsion and obtain an FP- containing fat emulsion having average particle diameter of preferably