N-ALKYLPHENYLSERINE DERIVATIVE AND PRODUCTION THEREOF

NEW MATERIAL:A compound expressed by formula I (R and R represent H, lower alkyl or aralkyl, except that both R and R are H at the same time; and R and R may link together to form alkylene). EXAMPLE:N-Ethyl-3-(3,4-dihydroxyphenyl)serine. USE:An antidepressant, anti-Parkinson's desease agent, pr...

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Bibliographische Detailangaben
Hauptverfasser:	HAYASHI MASAHIRO, SAWAZAKI YOSHIO, IHARA MASAKI
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Beschreibung
Zusammenfassung:	NEW MATERIAL:A compound expressed by formula I (R and R represent H, lower alkyl or aralkyl, except that both R and R are H at the same time; and R and R may link together to form alkylene). EXAMPLE:N-Ethyl-3-(3,4-dihydroxyphenyl)serine. USE:An antidepressant, anti-Parkinson's desease agent, preventive or remedial agent on presbyophrenia, etc. The compound is also useful as an ameliorating and remedial agent on deseases of cardiovascular system and exhibits inhibitory action on an body-temperature-decreasing action caused by reserpine. PREPARATION:A phenylserine derivative expressed by formula II (R represents H or protecting group) is subjected to reduction with condensation with an aldehyde or ketone expressed by formula III in a solvent such as a hydrous alcohol in the presence of a reducing agent (example; sodium boron hydride) at 0-50 deg.C for 0.5-10hr to obtain the compound expressed by formula I.