HUMAN CALCITONIN PRECURSOR PEPTIDE AND PRODUCTION THEREOF

NEW MATERIAL:A compound expressed by formula I (P is peptide residue having amino acid sequence of human calcitonin). USE:A remedy for hypercalcemia, Behcet's disease, etc. PREPARATION:For example, a microorganism, e.g. Escherichia coli, etc. is transformed with a plasmid containing a DNA conta...

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Bibliographische Detailangaben
Hauptverfasser: KIMIZUKA FUSAO, OBAYASHI AKIRA, KOMINE YURIKO, KONDO AKIHIRO, KINOSHITA RITSU, ISHINO YOSHIZUMI
Format: Patent
Sprache:eng
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Zusammenfassung:NEW MATERIAL:A compound expressed by formula I (P is peptide residue having amino acid sequence of human calcitonin). USE:A remedy for hypercalcemia, Behcet's disease, etc. PREPARATION:For example, a microorganism, e.g. Escherichia coli, etc. is transformed with a plasmid containing a DNA containing a gene capable of coding a peptide expressed by formula II (n is a positive integer) and then cultivated in a culture medium to produce a fused protein containing the peptide expressed by formula II in the resultant culture. The above-mentioned fused protein is then treated with an enzyme, e.g. trypsin, etc., to afford the aimed human calcitonin precursor peptide expressed by formula I.