DIHYDROPYRIDINE-5-PHOSPHONAMIDIC ACID COMPOUND

NEW MATERIAL:The compound of formula I {X and X are H, nitro, trifluoromethyl, lower alkyl, (halogen-substituted) lower alkoxy, F or Cl; R and R are H, 1-6C alkyl or R and R together form (substituted) 1,4-butylene; R is 1-10C alkyl or R and R together form (substituted) ethylene, etc.; Y is 1-4C al...

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Hauptverfasser:	SAKOTA RYOZO, KAMIKAWAJI MASUMASA, TANAKA SAKUYA, SETO KIYOTOMO
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	NEW MATERIAL:The compound of formula I {X and X are H, nitro, trifluoromethyl, lower alkyl, (halogen-substituted) lower alkoxy, F or Cl; R and R are H, 1-6C alkyl or R and R together form (substituted) 1,4-butylene; R is 1-10C alkyl or R and R together form (substituted) ethylene, etc.; Y is 1-4C alkyl, group of formula II [R and R are (substituted) 1-4C alkyl] or group of formula III} and its salt. EXAMPLE:5-(Ethoxy-N, N-dimethylamino-phosphinyl)-2,6-dimethyl-4-(3-chlorophe ny-l)--1,4-dihydropyridine-3-carboxylic acid 2-(N-benzyl-N-methylamino)-ethyl ester. USE:A remedy for circulatory diseases. PREPARATION:The compound of formula IV is made to react with the comopund of formula V.