INHIBITOR AGAINST OPIOID HYDROLYZING ENZYME
NEW MATERIAL:An organogermanium compound expressed by formula I [R1 is lower alkyl; R2-R4 are H, lower alkyl or (substituted) phenyl; Z is carboxyl, benzylaminomethyl or hydrochloride thereof]. EXAMPLE:(n-C3H7)GeCH2CH2COOH. USE:An inhibitor against opioid hydrolyzing enzymes and analgesi capable of...
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| creator | YOSHIHARA TORU KAKIMOTO NORIHIRO HASATO TADAHIKO |
| description | NEW MATERIAL:An organogermanium compound expressed by formula I [R1 is lower alkyl; R2-R4 are H, lower alkyl or (substituted) phenyl; Z is carboxyl, benzylaminomethyl or hydrochloride thereof]. EXAMPLE:(n-C3H7)GeCH2CH2COOH. USE:An inhibitor against opioid hydrolyzing enzymes and analgesi capable of selectively inhibiting enzymes hydrolyzing enkephalin which is one kind of endogenous morphinic substance, e.g. aminopeptidase derived from simian brains, etc., in a low concentration. PREPARATION:For example, trichlorogermylpropionic acid expressed by formula III is reacted with a Grignard reagent expressed by the formula R1MgX in a solvent e.g. ethyl ether, etc., while heating and refluxing according to the reaction formula and the resultant product is then hydrolyzed with hydrochloric acid. |
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EXAMPLE:(n-C3H7)GeCH2CH2COOH. USE:An inhibitor against opioid hydrolyzing enzymes and analgesi capable of selectively inhibiting enzymes hydrolyzing enkephalin which is one kind of endogenous morphinic substance, e.g. aminopeptidase derived from simian brains, etc., in a low concentration. PREPARATION:For example, trichlorogermylpropionic acid expressed by formula III is reacted with a Grignard reagent expressed by the formula R1MgX in a solvent e.g. ethyl ether, etc., while heating and refluxing according to the reaction formula and the resultant product is then hydrolyzed with hydrochloric acid.</description><language>eng</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>1987</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19870731&DB=EPODOC&CC=JP&NR=S62175176A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19870731&DB=EPODOC&CC=JP&NR=S62175176A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YOSHIHARA TORU</creatorcontrib><creatorcontrib>KAKIMOTO NORIHIRO</creatorcontrib><creatorcontrib>HASATO TADAHIKO</creatorcontrib><title>INHIBITOR AGAINST OPIOID HYDROLYZING ENZYME</title><description>NEW MATERIAL:An organogermanium compound expressed by formula I [R1 is lower alkyl; R2-R4 are H, lower alkyl or (substituted) phenyl; Z is carboxyl, benzylaminomethyl or hydrochloride thereof]. EXAMPLE:(n-C3H7)GeCH2CH2COOH. USE:An inhibitor against opioid hydrolyzing enzymes and analgesi capable of selectively inhibiting enzymes hydrolyzing enkephalin which is one kind of endogenous morphinic substance, e.g. aminopeptidase derived from simian brains, etc., in a low concentration. PREPARATION:For example, trichlorogermylpropionic acid expressed by formula III is reacted with a Grignard reagent expressed by the formula R1MgX in a solvent e.g. ethyl ether, etc., while heating and refluxing according to the reaction formula and the resultant product is then hydrolyzed with hydrochloric acid.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1987</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZND29PPwdPIM8Q9ScHR39PQLDlHwD_D093RR8Ih0CfL3iYzy9HNXcPWLivR15WFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8V4BwWZGhuamhuZmjsbEqAEAohglng</recordid><startdate>19870731</startdate><enddate>19870731</enddate><creator>YOSHIHARA TORU</creator><creator>KAKIMOTO NORIHIRO</creator><creator>HASATO TADAHIKO</creator><scope>EVB</scope></search><sort><creationdate>19870731</creationdate><title>INHIBITOR AGAINST OPIOID HYDROLYZING ENZYME</title><author>YOSHIHARA TORU ; KAKIMOTO NORIHIRO ; HASATO TADAHIKO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPS62175176A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1987</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>YOSHIHARA TORU</creatorcontrib><creatorcontrib>KAKIMOTO NORIHIRO</creatorcontrib><creatorcontrib>HASATO TADAHIKO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YOSHIHARA TORU</au><au>KAKIMOTO NORIHIRO</au><au>HASATO TADAHIKO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>INHIBITOR AGAINST OPIOID HYDROLYZING ENZYME</title><date>1987-07-31</date><risdate>1987</risdate><abstract>NEW MATERIAL:An organogermanium compound expressed by formula I [R1 is lower alkyl; R2-R4 are H, lower alkyl or (substituted) phenyl; Z is carboxyl, benzylaminomethyl or hydrochloride thereof]. EXAMPLE:(n-C3H7)GeCH2CH2COOH. USE:An inhibitor against opioid hydrolyzing enzymes and analgesi capable of selectively inhibiting enzymes hydrolyzing enkephalin which is one kind of endogenous morphinic substance, e.g. aminopeptidase derived from simian brains, etc., in a low concentration. PREPARATION:For example, trichlorogermylpropionic acid expressed by formula III is reacted with a Grignard reagent expressed by the formula R1MgX in a solvent e.g. ethyl ether, etc., while heating and refluxing according to the reaction formula and the resultant product is then hydrolyzed with hydrochloric acid.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | INHIBITOR AGAINST OPIOID HYDROLYZING ENZYME |
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